Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology

Author:

Ash Peter E A1ORCID,Dhawan Uma12,Boudeau Samantha1,Lei Shuwen1,Carlomagno Yari3,Knobel Mark1,Al Mohanna Louloua F A1,Boomhower Steven R4,Newland M Christopher5,Sherr David H6,Wolozin Benjamin17

Affiliation:

1. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts 02118

2. Department of Biomedical Science, Bhaskaracharya College of Applied Sciences, University of Delhi, Delhi 110075, India

3. Neuroscience Division, Mayo Clinic, Jacksonville, Florida 32224

4. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115

5. Department of Psychology, Auburn University, Auburn, Alabama 36849

6. Department of Environmental Health, Boston University School of Public Health

7. Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118

Funder

NIH

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference59 articles.

1. Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation;Afroz;Nat. Commun,2017

2. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis;Arai;Biochem. Biophys. Res. Commun,2006

3. Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists and criteria for their selection and use;Aschner;Altex,2017

4. Dioxins and related environmental contaminants increase TDP-43 levels;Ash;Mol. Neurodegener,2017

5. Advancing the science of developmental neurotoxicity (DNT): Testing for better safety evaluation;Bal-Price;ALTEX,2012

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