Quantitative Systems Toxicology Analysis ofIn VitroMechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury-Reference-Cited by-同舟云学术

Quantitative Systems Toxicology Analysis ofIn VitroMechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

Published:2018-10-05 Issue:2 Volume:167 Page:458-467
ISSN:1096-6080
Container-title:Toxicological Sciences
language:en
Short-container-title:

Author:

Longo Diane M¹,Woodhead Jeffrey L¹,Walker Paul²,Herédi-Szabó Krisztina³,Mogyorósi Károly³,Wolenski Francis S⁴,Dragan Yvonne P⁴,Mosedale Merrie⁵⁶^ORCID,Siler Scott Q¹,Watkins Paul B¹⁵⁶,Howell Brett A¹

Affiliation:

1. DILIsym Services, Inc., Research Triangle Park, North Carolina 27709

2. Cyprotex, Inc., Macclesfield SK10 4TG, UK

3. SOLVO Biotechnology, Szeged 6728, Hungary

4. Takeda Pharmaceuticals International, Inc., Cambridge, Massachusetts 02139

5. UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599

6. UNC Institute for Drug Safety Sciences, University of North Carolina at Chapel Hill, Research Triangle Park, North Carolina 27709

Funder

DILI-sim Initiative

Publisher

Oxford University Press (OUP)

Subject