Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: a Mathematically Based Toxicokinetic Model-Reference-Cited by-同舟云学术

Estimation of the Upper Limit of Human Butyrylcholinesterase Dose Required for Protection against Organophosphates Toxicity: a Mathematically Based Toxicokinetic Model

Published:2004-02 Issue:2 Volume:77 Page:358-367
ISSN:1096-6080
Container-title:Toxicological Sciences
language:en
Short-container-title:

Author:

Ashani Yacov,Pistinner Shlomi

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Link

http://academic.oup.com/toxsci/article-pdf/77/2/358/16691549/z1200204000358.pdf

Reference40 articles.

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2. Ashani, Y., Grauer, E., Grunwald, J., Allon, N., and Raveh, L. (1998). Current capabilities in extrapolating from animal to human the capacity of human butyrylcholinesterases to detoxify organophosphates. In Structure and Function of Cholinesterases and Related Proteins (B. P. Doctor, P. Taylor, D. M. Quinn, R. L. Rotundo, and M. K. Gentry, Eds.), pp. 255–260. Plenum Press, New York.

3. Ashani, Y., Shapira, S., Levy, D., Wolfe, A. D., Doctor, B. P., and Raveh, L. (1991). Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice. Biochem. Pharmacol.41,37–41.

4. Benschop, H. P., Konings, C. A. G., van Genderen, J., and de Jong, L. P. A. (1984). Isolation, anticholinesterase properties and acute toxicity in mice of four stereoisomers of the nerve agent soman. Toxicol. Appl. Pharmacol.72,61–74.

5. Boter, H. L., and van Dijk, C. (1969). Stereospecificity of hydrolytic enzymes on reaction with asymmetric organophosphorous compounds. III. The inhibition of acetylcholinesterase and butyrylcholinesterases by enantiomeric forms of sarin. Biochem. Pharmacol.18,2403–2407.

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