1. Department of Public Health Sciences and Pediatrics, University of Turin , C.so Galileo Galilei 22, Turin 10126 , Italy
2. Department of Chemistry , Life Sciences and Environmental Sustainability, , Parco Area delle Scienze 11/a, Parma 43124 , Italy
3. University of Parma , Life Sciences and Environmental Sustainability, , Parco Area delle Scienze 11/a, Parma 43124 , Italy
4. Department of Medical Sciences, University of Turin , Via Santena 5, Turin 10126 , Italy
5. Barcelona Supercomputing Centre (BSC-CNS) , Department of Life Sciences, Plaça Eusebi Güell, 1-3, Barcelona 08034 , Spain
6. Institute for Research in Biomedicine (IRB Barcelona), Department of Mechanisms of Disease, The Barcelona Institute of Science and Technology , Baldiri Reixac, 10, Barcelona 08028 , Spain
7. Department of Biology, University of Oxford , 11a Mansfield Rd, Oxford OX1 3SZ , United Kingdom