Affiliation:
1. Karolinska Institutet Department of Medical Biochemistry and Biophysics, Division of Molecular Metabolism, , Solnavägen 9, Solna 171 65, Sweden
Abstract
Abstract
Mitochondrial translation is a complex process responsible for the synthesis of essential proteins involved in oxidative phosphorylation, a fundamental pathway for cellular energy production. Central to this process is the termination phase, where dedicated factors play a pivotal role in ensuring accurate and timely protein production. This review provides a comprehensive overview of the current understanding of translation termination in human mitochondria, emphasizing structural features and molecular functions of two mitochondrial termination factors mtRF1 and mtRF1a.
Funder
Knut and Alice Wallenberg Foundation
Karolinska Institute
Swedish Research Council
Horizon 2020 - Marie Sklodowska-Curie Innovative Training Network
Deutsche Forschungsgesellschaft
David and Astrid Hagelén Foundation
Publisher
Oxford University Press (OUP)