Assessing cardiac mechanics through left ventricular haemodynamic forces

Author:

Aimo Alberto12ORCID,Panichella Giorgia3ORCID,Fabiani Iacopo2,Garofalo Manuel3,Fanizzi Angela Ilaria3,Ragagnin Maddalena3,Milazzo Alessandra3ORCID,Zocchi Chiara4,Del Franco Annamaria3ORCID,Pedrizzetti Gianni5ORCID,Olivotto Iacopo6ORCID,Emdin Michele12ORCID

Affiliation:

1. Interdisciplinary Center for Health Sciences, Scuola Superiore Sant'Anna , piazza Martiri della Libertà 33, 56127 Pisa , Italy

2. Cardiology Division, Fondazione Toscana Gabriele Monasterio , via Moruzzi 1, 56124 Pisa , Italy

3. Department of Experimental and Clinical Medicine, University of Florence , 50121 Florence , Italy

4. Cardiovascular Department, San Donato Hospital , 52100 Arezzo , Italy

5. Department of Engineering and Architecture, University of Trieste , Trieste , Italy

6. Meyer University Hospital , 50139 Florence , Italy

Abstract

Abstract Haemodynamic forces (HDFs), which represent the forces exchanged between blood and surrounding tissues, are critical in regulating the structure and function of the left ventricle (LV). These forces can be assessed on cardiac magnetic resonance or transthoracic echocardiography exams using specialized software, offering a non-invasive alternative for measuring intraventricular pressure gradients. The analysis of HDFs can be a valuable tool in improving our understanding of cardiovascular disease and providing insights beyond traditional diagnostic and therapeutic approaches. For instance, HDF analysis has the potential to identify early signs of adverse remodelling and cardiac dysfunction, which may not be detected by standard imaging methods such as bidimensional or speckle-tracking echocardiography. This review aims to summarize the principles of HDF analysis and to reappraise its possible applications to cardiac disorders.

Publisher

Oxford University Press (OUP)

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