1. Department of Immunology, University of Washington, Seattle, WA 98195, 2Center for Immunity and Immunotherapies, Seattle Children's Hospital Research Institute, Seattle WA 98177, 3Department of Biochemistry, University of Washington, Seattle, WA 98195, 4Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle WA 98109 and 5Department of Pediatrics, University of Washington, Seattle, WA 98195, USA