National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries

Author:

,Taddei Cristina,Jackson Rod,Zhou Bin,Bixby Honor,Danaei Goodarz,Di Cesare Mariachiara,Kuulasmaa Kari,Hajifathalian Kaveh,Bentham James,Bennett James E,Aekplakorn Wichai,Cifkova Renata,Dallongeville Jean,DeBacquer Dirk,Giampaoli Simona,Gudnason Vilmundur,Khang Young-Ho,Laatikainen Tiina,Mann JimI,Marques-Vidal Pedro,Mensah George A,Müller-Nurasyid Martina,Ninomiya Toshiharu,Petkeviciene Janina,Rodríguez-Artalejo Fernando,Servais Jennifer,Söderberg Stefan,Stavreski Bill,Wilsgaard Tom,Zdrojewski Tomasz,Zhao Dong,Stevens Gretchen A,Savin Stefan,Cowan Melanie J,Riley Leanne M,Ezzati MajidORCID,Adams Robert J,Aekplakorn Wichai,Ahrens Wolfgang,Amouyel Philippe,Amuzu Antoinette,Anderssen Sigmund A,Ariansen Inger,Arveiler Dominique,Aspelund Thor,Auvinen Juha,Avdicová Mária,Banach Maciej,Bandosz Piotr,Banegas José R,Barbagallo Carlo M,Bata Iqbal,Baur Louise A,Beaglehole Robert,Bennett James E,Bernotiene Gailute,Bi Yufang,Bienek Asako,Björkelund Cecilia,Bo Simona,Boehm Bernhard O,Bonaccio Marialaura,Bongard Vanina,Borchini Rossana,Borghs Herman,Breckenkamp Juergen,Brenner Hermann,Bruno Graziella,Busch Markus A,Cabrera de León Antonio,Capuano Vincenzo,Casanueva Felipe F,Casas Juan-Pablo,Caserta Carmelo A,Censi Laura,Chen Fangfang,Chen Shuohua,Chirlaque María-Dolores,Cho Belong,Cho Yumi,Chudek Jerzy,Cifkova Renata,Claessens Frank,Clarke Janine,Clays Els,Cooper Cyrus,Costanzo Simona,Cottel Dominique,Cowell Chris,Crujeiras Ana B,Cui Liufu,D'Arrigo Graziella,Dallongeville Jean,Dauchet Luc,De Backer Guy,De Bacquer Dirk,de Gaetano Giovanni,De Henauw Stefaan,De Smedt Delphine,Dennison Elaine,Deschamps Valérie,DiCastelnuovo Augusto,Dobson Annette J,Donfrancesco Chiara,Döring Angela,Drygas Wojciech,Du Yong,Dziankowska-Zaborszczyk Elzbieta,Eggertsen Robert,Ekelund Ulf,Elosua Roberto,Eriksson Johan G,Evans Alun,Faeh David,Felix-Redondo Francisco J,Fernández-Bergés Daniel,Ferrari Marika,Ferrieres Jean,Finn Joseph D,Forslund Ann-Sofie,Forsner Maria,Frontera Guillermo,Fujita Yuki,Gaciong Zbigniew,Galvano Fabio,Gao Jingli,Garcia-de-la-Hera Manoli,Garnett Sarah P,Gaspoz Jean-Michel,Gasull Magda,Gates Louise,Giampaoli Simona,Gianfagna Francesco,Gill Tiffany K,Giovannelli Jonathan,Goltzman David,GonzalezGross Marcela,Gottrand Frederic,Graff-Iversen Sidsel,Grafnetter Dušan,Gregor Ronald D,Grodzicki Tomasz,Grosso Giuseppe,Gruden Grabriella,Gu Dongfeng,Guallar-Castillón Pilar,Gudmundsson Elias F,Gudnason Vilmundur,Guessous Idris,Gunnlaugsdottir Johanna,Gutzwiller Felix,Hardy Rebecca,Hata Jun,Haugsgjerd Teresa,Hayes Alison J,He Jiang,He Yuna,Herrala Sauli,TapaniHihtaniemi Ilpo,Hobbs Michael,Hopman Wilma M,MaríaHuerta José,Huybrechts Inge,Iacoviello Licia,Iannone Anna G,Ikeda Nayu,Iwasaki Masanori,Jackson Rod,Jamrozik Konrad,Janszky Imre,Jarvelin Marjo-Riitta,Jasienska Grazyna,Jennings Garry,Jeong Seung-lyeal,QiangJiang Chao,Joffres Michel,Jokelainen Jari J,Jonas Jost B,Jóźwiak Jacek,Kajantie Eero O,Kauhanen Jussi,Keil Ulrich,Keinänen-Kiukaanniemi Sirkka,Kersting Mathilde,Khang Young-Ho,Kiechl-Kohlendorfer Ursula,Kiechl Stefan,Kim Jeongseon,Kim Yeon-Yong,Klumbiene Jurate,Knoflach Michael,Ko Stephanie,Kolle Elin,Korpelainen Raija,Koskinen Seppo,Kouda Katsuyasu,Kratzer Wolfgang,Kriemler Susi,Krokstad Steinar,Kujala Urho M,Kurjata Pawel,Kuulasmaa Kari,Laatikainen Tiina,HingLam Tai,Lanska Vera,Lappas Georg,Laugsand Lars E,Lee Jeonghee,Lehtimäki Terho,Li Yanping,Lilly Christa L,Lin Xu,Lind Lars,Lissner Lauren,Liu Jing,Lopez-Garcia Esther,Lorbeer Roberto,EugenioLozano José,Luksiene Dalia,Lundqvist Annamari,Lundqvist Robert,Lytsy Per,Ma Guansheng,Machi Suka,Maggi Stefania,Magliano Dianna J,Mann JimI,Manzato Enzo,Marques-Vidal Pedro,Mathiesen Ellisiv B,McLachlan Stela,McLean Rachael M,McLean Scott B,Meirhaeghe Aline,Meisinger Christa,Metcalf Patricia,Mi Jie,Miller Jody C,Moreno Luis A,Morin Suzanne,Mossakowska Malgorzata,Muiesan Maria L,Müller-Nurasyid Martina,Mursu Jaakko,Nakamura Harunobu,Námešná Jana,Nauck Matthias,MariaNavarrete-Muñoz Eva,Neal William A,Nenko Ilona,Niiranen Teemu J,Ning Guang,Ninomiya Toshiharu,Noale Marianna,Norie Sawada,Noto Davide,O'Neill Terence,O'Reilly Dermot,Oh Kyungwon,Olafsson Örn,MichelPaccaud Fred,Pajak Andrzej,Palmieri Luigi,Panza Francesco,Parnell Winsome R,Peltonen Markku,Peters Annette,Petersmann Astrid,Petkeviciene Janina,Pigeot Iris,Pilotto Lorenza,Piwonska Aleksandra,Plans-Rubió Pedro,Porta Miquel,Price Jacqueline F,Puder Jardena J,Puhakka Soile E,Radisauskas Ricardas,Raitakari Olli,Ramos Rafel,Redon Josep,Rigo Fernando,Rodríguez-Artalejo Fernando,Rodriguez-Perez MaríadelCristo,Romaguera Dora,Ronkainen Kimmo,Rosengren Annika,Roy Joel G R,Ruidavets Jean-Bernard,Rutkowski Marcin,Salanave Benoit,Salmerón Diego,Salomaa Veikko,Salonen Jukka T,Salvetti Massimo,Sans Susana,Saramies Jouko L,Saum Kai-Uwe,Scheidt-Nave Christa,Schienkiewitz Anja,Schipf Sabine,Schmidt Carsten O,Schöttker Ben,Sebert Sylvain,Sen Abhijit,Servais Jennifer,Shaw Jonathan E,Shibuya Kenji,WookShin Dong,Shiri Rahman,Simons Judith,Simons Leon A,Sjöström Michael,Slowikowska-Hilczer Jolanta,Slusarczyk Przemyslaw,Söderberg Stefan,Solfrizzi Vincenzo,Sonestedt Emily,Soumare Aicha,Staessen Jan A,Stathopoulou Maria G,Stavreski Bill,Steene-Johannessen Jostein,Stehle Peter,Stieber Jutta,Stöckl Doris,Stokwiszewski Jakub,Sundström Johan,Suriyawongpaisal Paibul,Tamosiunas Abdonas,JooTan Eng,Taylor Anne,Tell Grethe,Thijs Lutgarde,Tolonen HannaK,Topór-Madry Roman,JoséTormo María,Torrent Maties,Tsugane Shoichiro,Tuomainen Tomi-Pekka,Tuomilehto Jaakko,Tzourio Christophe,Uusitalo Hannu M T,Van Herck Koen,Vanderschueren Dirk,Vanuzzo Diego,Vatten Lars,Vega Tomas,Veronesi Giovanni,Vioque Jesus,Virtanen JyrkiK,Visvikis-Siest Sophie,Vollenweider Peter,Voutilainen Sari,Vrijheid Martine,Wagner Aline,Wagner Anne,Wang Ming-Dong,Wang Qian,XingWang Ya,Wannamethee S Goya,Wei Wenbin,Whincup Peter H,Wiecek Andrzej,Willeit Johann,Willeit Peter,Wilsgaard Tom,Wojtyniak Bogdan,Wong Andrew,Woodward Mark,GiwercmanWu Aleksander,Wu Frederick C,Wu Shouling,Xu Haiquan,Xu Liang,Yan Weili,Yang Xiaoguang,Ye Xingwang,Yoshihara Akihiro,Zambon Sabina,Zdrojewski Tomasz,Zhao Dong,Zhao Wenhua

Abstract

Abstract Background Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.

Funder

Wellcome Trust

Research Training Fellowship

Ministry of Health of the Czech Republic

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Epidemiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3