Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study-Reference-Cited by-同舟云学术

Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study

Published:2019-05-25 Issue:2 Volume:70 Page:323-326
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Steiner Kevin L¹,Kabir Mamun²,Priest Jeffrey W³,Hossain Biplob²,Gilchrist Carol A¹,Cook Heather⁴,Ma Jennie Z⁵,Korpe Poonum S⁶,Ahmed Tahmeed²,Faruque A S G²,Haque Rashidul²,Petri William A¹

Affiliation:

1. Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville

2. icddr,b, Dhaka, Bangladesh

3. Division of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

4. Department of Statistics, School of Medicine, University of Virginia, Charlottesville

5. Division of Biostatistics, Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville

6. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

Abstract

Abstract In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

Funder

National Institutes of Health

Bill and Melinda Gates Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciz430/28848847/ciz430.pdf

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