Infectious diseases acquired by international travellers visiting the USA†
Author:
Stoney Rhett J1ORCID, Esposito Douglas H1, Kozarsky Phyllis12, Hamer Davidson H34ORCID, Grobusch Martin P5, Gkrania-Klotsas Effrossyni6, Libman Michael7, Gautret Philippe8, Lim Poh Lian910, Leder Karin1112ORCID, Schwartz Eli1314, Sotir Mark J1, Licitra Carmelo15, Goorhuis Abraham, McCarthy Anne, Thomas Ashley, Warne Ben, Connor Brad, Schade Larsen Carsten, Wejse Christian, Perret-Perez Cecilia, Yansouni Cedric, Rapp Christophe, Ficko Cecile, Lalloo David, Beeching Nicholas, Anderson Susan, Javelle Emilie, Bottieau Emmanuel, Clerinx Joannes, Caumes Eric, Perignon Alice, Castelli Francesco, Matteelli Alberto, Chappuis Francois, Mockenhaupt Frank, Harms-Zwigenberger Gundel, von Sonnenburg Frank, Rothe Camilla, Asgeirsson Hilmir, Glans Hedvig, Siu Hugo, Manuel Valdez Luis, Haulman Jean, Terry Anne, Vincelette Jean, Barkati Sapha, Cahill John, McKinley George, Flores-Figueroa Jose, Torresi Joseph, Plewes Katherine, Ghesquire Wayne, Mirzanejad Yazdan, Kain Kevin, Boggild Andrea, Mendelson Marc, Parker Salim, Shaw Marc, Jensenius Mogens, Schlagenhauf Pat, Weber Rainer, Kelly Paul, Van Genderen Perry, Hoang Phu Phi Truong, Pandey Prativa, Murphy Holly, Lopez-Velez Rogelio, Norman Francesca, Jordan Sabine, Vinnemeier Christof, Borwein Sarah, Kanagawa Shuzo, Kato Yasuyuki, Kuhn Susan, Piyaphanee Watcharapong, Silachamroon Udomsak, Yoshimura Yokihiro, Tachikawa Natsuo,
Affiliation:
1. Travelers’ Health Branch, Division of Global Migration and Quarantine, Centers for Disease Control and Prevention (CDC), 1825 Century Blvd NE, MS E-28, Atlanta, GA, USA 2. Department of Medicine, Emory University, Atlanta, GA, USA 3. Department of Global Health, Boston University School of Public Health, Boston, MA, USA 4. Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, MA, USA 5. Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 6. Division of Infectious Diseases, Cambridge University Hospitals, Cambridge, UK 7. J.D. MacLean Centre for Tropical Diseases, McGill University, Montreal, Canada 8. Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France 9. Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore 10. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 11. School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia 12. Victorian Infectious Disease Service, Royal Melbourne Hospital at the Doherty Institute, Melbourne, Australia 13. Institute of Geographic Medicine and Tropical Diseases, Sheba Medical Center, Tel Hashomer, Israel 14. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 15. Orlando Health Infectious Disease, University of Central Florida College of Medicine, Orlando, FL, USA
Abstract
Abstract
Background
Estimates of travel-related illness have focused predominantly on populations from highly developed countries visiting low- or middle-income countries, yet travel to and within high-income countries is very frequent. Despite being a top international tourist destination, few sources describe the spectrum of infectious diseases acquired among travellers to the USA.
Methods
We performed a descriptive analysis summarizing demographic and travel characteristics, and clinical diagnoses among non-US-resident international travellers seen during or after travel to the USA at a GeoSentinel clinic from 1 January 1997 through 31 December 2016.
Results
There were 1222 ill non-US-resident travellers with 1393 diagnoses recorded during the 20-year analysis period. Median age was 40 (range 0–86 years); 52% were female. Patients visited from 63 countries and territories, most commonly Canada (31%), Germany (14%), France (9%) and Japan (7%). Travellers presented with a range of illnesses; skin and soft tissue infections of unspecified aetiology were the most frequently reported during travel (29 diagnoses, 14% of during-travel diagnoses); arthropod bite/sting was the most frequently reported after travel (173 diagnoses, 15% after-travel diagnoses). Lyme disease was the most frequently reported arthropod-borne disease after travel (42, 4%). Nonspecific respiratory, gastrointestinal and systemic infections were also among the most frequently reported diagnoses overall. Low-frequency illnesses (<2% of cases) made up over half of diagnoses during travel and 41% of diagnoses after travel, including 13 cases of coccidioidomycosis and mosquito-borne infections like West Nile, dengue and Zika virus diseases.
Conclusions
International travellers to the USA acquired a diverse array of mostly cosmopolitan infectious diseases, including nonspecific respiratory, gastrointestinal, dermatologic and systemic infections comparable to what has been reported among travellers to low- and middle-income countries. Clinicians should consider the specific health risks when preparing visitors to the USA and when evaluating and treating those who become ill.
Funder
International Society of Travel Medicine
Publisher
Oxford University Press (OUP)
Cited by
17 articles.
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