Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts

Author:

Yokoyama Yoshie1,Jelenkovic Aline23,Hur Yoon-Mi4,Sund Reijo25,Fagnani Corrado6,Stazi Maria A6,Brescianini Sonia6,Ji Fuling7,Ning Feng7,Pang Zengchang7,Knafo-Noam Ariel8,Mankuta David9,Abramson Lior8,Rebato Esther3,Hopper John L1011,Cutler Tessa L10,Saudino Kimberly J12,Nelson Tracy L13,Whitfield Keith E14,Corley Robin P15,Huibregtse Brooke M15,Derom Catherine A1617,Vlietinck Robert F16,Loos Ruth J F18,Llewellyn Clare H19,Fisher Abigail19,Bjerregaard-Andersen Morten202122,Beck-Nielsen Henning22ORCID,Sodemann Morten23,Krueger Robert F24,McGue Matt24,Pahlen Shandell24,Bartels Meike25,van Beijsterveldt Catharina E M25,Willemsen Gonneke25,Harris Jennifer R26,Brandt Ingunn26,Nilsen Thomas S26,Craig Jeffrey M2728,Saffery Richard2728,Dubois Lise29,Boivin Michel3031,Brendgen Mara32,Dionne Ginette30,Vitaro Frank33,Haworth Claire M A34,Plomin Robert35,Bayasgalan Gombojav36,Narandalai Danshiitsoodol3637,Rasmussen Finn3839,Tynelius Per38,Tarnoki Adam D4041,Tarnoki David L4041,Ooki Syuichi42,Rose Richard J43,Pietiläinen Kirsi H4445,Sørensen Thorkild I A4647,Boomsma Dorret I25,Kaprio Jaakko4849,Silventoinen Karri250

Affiliation:

1. Department of Public Health Nursing, Osaka City University, Osaka, Japan

2. Department of Social Research, University of Helsinki, Helsinki, Finland

3. Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, Spain

4. Department of Education, Mokpo National University, Jeonnam, South Korea

5. Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland

6. Istituto Superiore di Sanità - National Center for Epidemiology, Surveillance and Health Promotion, Rome, Italy

7. Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China

8. Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel

9. Hadassah Hospital Obstetrics and Gynecology Department, Hebrew University Medical School, Jerusalem, Israel

10. Australian Twin Registry, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, VIC, Australia

11. Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea

12. Department of Psychological and Brain Sciencies, Boston University, Boston, MA, USA

13. Department of Health and Exercise Sciencies and Colorado School of Public Health, Colorado State University, Fort Collins, CO, USA

14. Psychology and Neuroscience, Duke University, Durham, NC, USA

15. Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA

16. Centre of Human Genetics, University Hospitals Leuven, Leuven, Belgium

17. Department of Obstetrics and Gynaecology, Ghent University Hospitals, Ghent, Belgium

18. Charles Bronfman Institute for Personalized Medicine, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

19. Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK

20. Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau

21. Research Center for Vitamins and Vaccines, Statens Serum Institute, Copenhagen, Denmark

22. Department of Endocrinology

23. Department of Infectious Diseases, Odense University Hospital, Odense, Denmark

24. Department of Psychology, University of Minnesota, Minneapolis, MN, USA

25. Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands

26. Department of Genetic Research and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway

27. Murdoch Childrens Research Institute, Royal Children’s Hospital, Parkville, VIC, Australia

28. Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia

29. School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, ON, Canada

30. École de psychologie, Université Laval, Québec, QC, Canada

31. Institute of Genetic, Neurobiological, and Social Foundations of Child Development, Tomsk State University, Tomsk, Tomskaya oblast', Russian Federation

32. Département de psychologie, Université du Québec à Montréal, Montréal, QC, Canada

33. École de psychoéducation, Université de Montréal, Montréal, QC, Canada

34. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK

35. King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK

36. Healthy Twin Association of Mongolia, Ulaanbaatar, Mongolia

37. Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

38. Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden

39. Department of Health Sciences, Lund University, Lund, Sweden

40. Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary

41. Hungarian Twin Registry, Budapest, Hungary

42. Department of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, Japan

43. Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA

44. Obesity Research Unit, University of Helsinki, Helsinki, Finland

45. Endocrinology, Abdominal Center, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland

46. Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

47. Department of Public Health, University of Copenhagen, Copenhagen, Denmark

48. Department of Public Health, University of Helsinki, Helsinki, Finland

49. Institute for Molecular Medicine FIMM, Helsinki, Finland?>

50. Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan

Funder

Academy of Finland

The Australian Twin Registry

Centre of Research Excellence

National Health and Medical Research Council

University of Melbourne

Boston University Twin

National Institutes of Health

Carolina African American Twin Study of Aging

CAATSA

National Institute on Aging

Colorado Twin Registry

Longitudinal Twin Study

East Flanders Prospective Survey

Fund of Scientific Research, Flanders and Twins

Association for Scientific Research in Multiple Births

ENGAGE

European Network for Genetic and Genomic Epidemiology

National Institute of Alcohol Abuse and Alcoholism

Center of Excellence in Complex Disease Genetics

Cancer Research UK

Medexpert Ltd, Budapest, Hungary

Italian Twin Registry

Chiesi Foundation

Longitudinal Israeli Study of Twins

European Research Council

ERC

Michigan State University Twin Registry

Michigan State University

National Institute of Mental Health

NIMH

Eunice Kennedy Shriver National Institute for Child Health and Human Development

NICHD

MSU Foundation

Norwegian Twin Registry

European Union’s Seventh Framework Programmes ENGAGE Consortium

BioSHaRE EU

Netherlands Twin Register

Netherlands Organization for Scientific Research

NWO

Avera Institute, Sioux Falls, South Dakota

Australian National Health and Medical Research Council

Bonnie Babes Foundation

Financial Markets Foundation for Children

Victorian Government’s Operational Infrastructure Support Program

Quebec Newborn Twin Study

Fonds Québécois de la Recherche sur la Société et la Culture

Fonds de la Recherche en Santé du Québec

Social Science and Humanities Research Council of Canada

National Health Research Development Program

Canadian Institutes for Health Research

Sainte-Justine Hospital’s Research Center

Canada Research Chair Program

The Twins Early Development Study

TEDS

UK Medical Research Council

Biotechnology and Biological Sciences Research Council

MRC

The West Japan Twins and Higher Order Multiple Births Registry

Grant-in-Aid for Scientific Research (B)

Japan Society for the Promotion of Science

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Epidemiology

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