Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers

Author:

Kim Shana J1,Huzarski Tomasz2,Gronwald Jacek2,Singer Christian F3,Møller Pål456,Lynch Henry T7,Armel Susan8,Karlan Beth Y9,Foulkes William D10,Neuhausen Susan L11,Senter Leigha12,Eisen Andrea13,Eng Charis14,Panchal Seema15,Pal Tuya16,Olopade Olufunmilayo17,Zakalik Dana18,Lubinski Jan2,Narod Steven A119,Kotsopoulos Joanne119,Ainsworth Peter,Bordeleau Louise,Tung Nadine,Friedman Eitan,Meschino Wendy,Snyder Carrie,Metcalfe Kelly,Warner Ellen,Rosen Barry,Demsky Rochelle,Weitzel Jeffrey N,Panabaker Karen,Couch Fergus,Manoukian Siranoush,Pasini Barbara,Daly Mary B,Steele Linda,Saal Howard,Fallen Taya,Wood Marie,McKinnon Wendy,Lemire Edmond,Chudley Albert E,Serfas Kim,Elser Christine,Vadaparampil Susan T,Ginsburg Ophira,Cullinane Carey A,Blum Joanne L,Ross Theodora,Mauer Caitlin,Kwong Ava,Cybulski Cezary,McCuaig Jeanna,Rayson Daniel,Isaacs Claudine,

Affiliation:

1. Women’s College Research Institute, Women’s College Hospital, Toronto, Ontario, Canada

2. Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland

3. Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria

4. Inherited Cancer Research Group, Department for Medical Genetics, Oslo University Hospital, Oslo, Norway

5. Department of Tumor Biology, Institute of Cancer Research, Oslo University Hospital, Oslo, Norway

6. Surgical Center for Hereditary Tumors, HELIOS University Clinic Wuppertal, University Witten-Herdecke, Wuppertal, Germany

7. Hereditary Cancer Center, Creighton University School of Medicine, Omaha, NE, USA

8. Department of Gynecologic Oncology, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada

9. Women’s Cancer Program, Division of Gynecologic Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

10. Program in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montréal, Quebec, Canada

11. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA

12. Division of Human Genetics, Ohio State University Medical Center, Comprehensive Cancer Center, Columbus, OH, USA

13. Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

14. Genomic Medicine Institute, Center for Personalized Genetic Healthcare, Cleveland Clinic, Cleveland, OH, USA

15. Mount Sinai Hospital, Toronto, Ontario, Canada

16. Vanderbilt-Ingram Cancer Center/Vanderbilt University Medical Center, Nashville, TN, USA

17. Department of Medicine, University of Chicago, Chicago, IL, USA

18. Cancer Genetics Program, Beaumont Hospital, Royal Oak, MI, USA

19. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Funder

Champions of Genetics

Canadian Gene Cure Foundation

Canadian Institutes of Health Research

CIHR

Institute of Genetics and Canadian Cancer Society Research Institute

Charles F. and Mary C. Heider Chair in Cancer Research

Creighton University

American Cancer Society Clinical Research Professorship

Morris and Horowitz Families Endowed Professorship

Canada Research Chair

Cancer Care Ontario Research Chair in Population Studies

Canadian Cancer Society Career Development Award in Prevention

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Epidemiology

Reference27 articles.

1. Body fatness at young ages and risk of breast cancer throughout life;Baer;Am J Epidemiol,2010

2. The interaction between early-life body size and physical activity on risk of breast cancer;Oh;Int J Cancer,2015

3. A prospective study of body size and breast cancer in black women;Palmer;Cancer Epidemiol Biomarkers Prev,2007

4. Weight and weight changes in early adulthood and later breast cancer risk;Rosner;Int J Cancer,2017

5. Body fatness throughout the life course and the incidence of premenopausal breast cancer;Xue;Int J Epidemiol,2016

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