1. Oxford Centre for Genomic Medicine, Oxford University Hospitals NHS Foundation Trust , Oxford OX3 7HE , UK
2. Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University , Oxford OX3 0BP , UK
3. Centre for Functional Genomics, Oxford Brookes University , Oxford OX3 0BP , UK
4. Spires Cleft Centre, John Radcliffe Hospital , Oxford OX3 9DU , UK
5. Radcliffe Department of Medicine, University of Oxford OX3 9DU, UK