Fabrication of mesoporous carbon with a large surface area to achieve sensitive electrochemical sensing for nitazoxanide drug determination in human serum

Author:

Abdel-Galeil Mohamed M12,El-Desoky Hanaa S2,El-Attar Mona3,Morita Shin-ichi1

Affiliation:

1. Chemistry Department, Graduate School of Science, Tohoku University , 6-3 Aramaki-Aza-Aoba, Aoba, Sendai 980-8578 , Japan

2. Chemistry Department, Faculty of Science, Tanta University , Elbahr street, Tanta 31527 , Egypt

3. High Institute of Engineering & Technology , Tanta 31527 , Egypt

Abstract

Abstract Mesoporous carbon (MC) with a large surface area was developed to mix with the conventional carbon paste (CP) electrode. The developed MC/CP sensor had the highest sensitivity compared to many sensors made from other materials. A common drug, nitazoxanide (NTZ), was used as an application example. Using the MC/CP electrode and square wave-adsorptive stripping voltammetry (SW-AdSV), the concentration of NTZ in human serum was quantitatively estimated. We achieved a limit of quantification (LOQ) of 22 nM.

Publisher

Oxford University Press (OUP)

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