1. Department of Medicinal Chemistry, Hokkaido University of Science , 7-15-4-1 Maeda Teine-ku, Sapporo 006-8585 , Japan
2. Creation Research of Life Science in KITA-no-DAICHI, Hokkaido University of Science , 7-15-4-1 Maeda Teine-ku, Sapporo 006-8585 , Japan