Synthesis and structural characterization of benzene-1,3-disulfonamide-containing 11- to 13-membered heterocycles via double Mitsunobu annulation-Reference-Cited by-同舟云学术

Synthesis and structural characterization of benzene-1,3-disulfonamide-containing 11- to 13-membered heterocycles via double Mitsunobu annulation

Published:2023-12-01 Issue:1 Volume:53 Page:
ISSN:0366-7022
Container-title:Chemistry Letters
language:en
Short-container-title:

Author:

Kaneda Kyosuke¹²^ORCID,Koideya Takato¹,Toshima Ryuji¹,Konno Yoshiki¹,Yamagishi Takehiro¹²

Affiliation:

1. Department of Medicinal Chemistry, Hokkaido University of Science , 7-15-4-1 Maeda Teine-ku, Sapporo 006-8585 , Japan

2. Creation Research of Life Science in KITA-no-DAICHI, Hokkaido University of Science , 7-15-4-1 Maeda Teine-ku, Sapporo 006-8585 , Japan

Abstract

Abstract The synthesis and 3D-conformation of several novel benzene-1,3-disulfonamides-containing 11- to 13-membered heterocycles have been achieved. Double Mitsunobu annulation was effective for the construction of medium to large ring systems in moderate chemical yields. In addition, the flexibility of sulfonamide moieties in these rings was determined by X-ray crystal structural analysis.

Funder

Shiono Wellness Foundation

Publisher

Oxford University Press (OUP)

Subject

General Chemistry

Link

https://academic.oup.com/chemlett/advance-article-pdf/doi/10.1093/chemle/upad016/53971880/upad016.pdf

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