Anion effects on the structure and stability of 3D domain–swapped cytochrome <i>c</i> dimer-Reference-Cited by-同舟云学术

Anion effects on the structure and stability of 3D domain–swapped cytochrome c dimer

Published:2024-07-31 Issue:8 Volume:53 Page:
ISSN:0366-7022
Container-title:Chemistry Letters
language:en
Short-container-title:

Author:

Fujiwara Kodai¹,Ryuzaki Michiko¹,Yamanaka Masaru¹,Mashima Tsuyoshi¹²,Saotome Tomonori³,Kidokoro Shun-ichi⁴,Hirota Shun¹^ORCID

Affiliation:

1. Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192 , Japan

2. Medilux Research Center, Graduate School of Science and Technology, Nara Institute of Science and Technology , 8916-5 Takayama, Ikoma, Nara 630-0192 , Japan

3. Department of Materials Chemistry and Bioengineering, National Institute of Technology, Oyama College , 771 Nakakuki, Oyama, Tochigi 323-0806 , Japan

4. Department of Materials Science and Bioengineering, Nagaoka University of Technology , 1603-1 Kamitomioka-cho, Nagaoka, Niigata 940-2188 , Japan

Abstract

Abstract The structure and stability of proteins are affected by ions. We have previously reported that cytochrome c can form a 3D domain–swapped dimer. The structure of the cytochrome c domain–swapped dimer becomes more compact in the presence of kosmotropic anions, whereas the thermal stability of the dimer decreased with addition of chaotropic anions based on the Hofmeister series. Dimers were formed by incubating cytochrome c at 50 °C in the presence of citrate ions.

Funder

Grants-in-Aid from JSPS for Scientific Research

JST CREST, Japan

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/chemlett/advance-article-pdf/doi/10.1093/chemle/upae150/58714839/upae150.pdf

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