Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration-Reference-Cited by-同舟云学术

Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

Published:2019-09-27 Issue:11 Volume:142 Page:3621-3635
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Bejanin Alexandre¹²^ORCID,Murray Melissa E³,Martin Peter⁴,Botha Hugo¹^ORCID,Tosakulwong Nirubol⁴,Schwarz Christopher G⁵,Senjem Matthew L⁵⁶,Chételat Gael²,Kantarci Kejal⁵,Jack Clifford R⁵,Boeve Bradley F¹,Knopman David S¹,Petersen Ronald C¹,Giannini Caterina⁷,Parisi Joseph E⁷,Dickson Dennis W³^ORCID,Whitwell Jennifer L⁵,Josephs Keith A¹

Affiliation:

1. Department of Neurology, Mayo Clinic, Rochester, MN, USA

2. Inserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France

3. Department of Neuroscience, Mayo Clinic, Florida, USA

4. Health Science Research, Mayo Clinic, Rochester, MN, USA

5. Department of Radiology, Mayo Clinic, Rochester, MN, USA

6. Department of Information Technology, Mayo Clinic, Rochester, MN, USA

7. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

Abstract

The specific effect of TDP-43 pathology on grey matter volume in individuals without frontotemporal lobar degeneration is unclear. Bejanin et al. reveal a major and independent contribution of TDP-43 to neurodegeneration and shed light on the regional distribution of TDP-43-related atrophy in older adults.

Funder

National Institutes of Health

Gerald and Henrietta Rauenhorst Foundation

Elsie and Marvin Dekelboum Family Foundation

Alexander Family Alzheimer’s Disease Research Professorship of the Mayo Clinic

Mayo Foundation for Medical Education and Research

Fondation Thérèse et René Planiol

Conseil Régional de Normandie

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)