Evolutionary modifications in human brain connectivity associated with schizophrenia

Author:

van den Heuvel Martijn P12,Scholtens Lianne H1ORCID,de Lange Siemon C1,Pijnenburg Rory1,Cahn Wiepke3,van Haren Neeltje E M34,Sommer Iris E35,Bozzali Marco67,Koch Kathrin89,Boks Marco P3,Repple Jonathan10,Pievani Michela11,Li Longchuan12,Preuss Todd M131415,Rilling James K1415161718

Affiliation:

1. Connectome Lab, Department of Complex Traits Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands

2. Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands

3. Department of Psychiatry, Brain Center University Medical Center Utrecht, Utrecht University, The Netherlands

4. Department of Child and Adolescent Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands

5. Department of Neuroscience and Department of Psychiatry, University Medical Center Groningen, The Netherlands

6. Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, East Sussex, UK

7. Neuroimaging Laboratory, Santa Lucia Foundation IRCCS, Rome, Italy

8. Department of Neuroradiology and TUM-Neuroimaging Center (TUM-NIC), School of Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

9. Graduate School of Systemic Neurosciences GSN, Ludwig-Maximilians-Universität, Biocenter, Munich, Germany

10. Department of Psychiatry, University of Muenster, Muenster, Germany

11. Lab Alzheimer’s Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy

12. Marcus Autism Center, Children’s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA

13. Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA

14. Center for Translational Social Neuroscience, Emory University, Atlanta, GA, USA

15. Center for Behavioral Neuroscience, Atlanta, GA, USA

16. Department of Anthropology, Emory University, 1557 Dickey Drive, Atlanta, GA 30322, USA

17. Department of Psychiatry and Behavioral Sciences, Emory University, 201 Dowman Drive, Atlanta, GA 30322, USA

18. Division of Developmental and Cognitive Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA

Abstract

See Vértes and Seidlitz (doi:10.1093/brain/awz353) for a scientific commentary on this article.Is schizophrenia a by-product of human brain evolution? By comparing the human and chimpanzee connectomes, van den Heuvel et al. demonstrate that connections unique to the human brain show greater involvement in schizophrenia pathology. Modifications in service of higher-order brain functions may have rendered the brain more vulnerable to dysfunction.

Funder

Mind Research Network

Center of Biomedical Research Excellence

COBRE

VIDI

Netherlands Organization for Scientific Research

Mental Health and Quality of Life fellowship

National Institutes of Health

National Center for Research Resources

Office of Research Infrastructure Programs

Yerkes National Primate Research Center

National Chimpanzee Brain Resource

National Institute of Mental Health

Human Connectome Project, WU-Minn Consortium

NIH Institutes and Centers

NIH Blueprint for Neuroscience Research

McDonnell Center for Systems Neuroscience at Washington University

Italian Ministry of Health

Dutch Organization for Scientific Research

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

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