Ubiquitin-related network underlain by (CAG)n loci modulate age at onset in Machado-Joseph disease

Author:

Chen Zhao1,Wang Chunrong1,Zheng Caifa1,Long Zhe1,Cao Li2,Li Xunhua3,Shang Huifang4,Yin Xinzhen5,Zhang Baorong5,Liu Jingyu6,Ding Dongxue1,Peng Yun1,Peng Huirong1,Ye Wei1,Qiu Rong7,Pan Qian8,Xia Kun8,Chen Shengdi2,Sequeiros Jorge9,Ashizawa Tetsuo10,Tang Beisha18111213,Jiang Hong181214,

Affiliation:

1. Department of Neurology Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China

2. Department of Neurology and Institute of Neurology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, P. R. China

3. Department of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, P. R. China

4. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China

5. Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310009, P. R. China

6. Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, P. R. China

7. School of Information Science and Engineering, Central South University, Changsha, Hunan, 410083, P. R. China

8. State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, P. R. China

9. IBMC - Institute for Molecular and Cell Biology, i3S - Instituto de Investigação e Inovação na Saúde; and ICBAS; Univ. Porto, Portugal

10. Department of Neurology, Houston Methodist Neurological Institute & Houston Methodist Research Institute, R11-117, 6670 Bertner Avenue, Houston, TX, 77030, USA

11. National Clinical Research Center for Geriatric Diseases, Changsha, Hunan 410078, P. R. China

12. Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, P. R. China

13. Parkinson’s Disease Center of Beijing Institute for Brain Disorders, Beijing 100069, P. R. China

14. Xinjiang Medical University, Xinjiang, 830011, P. R. China

Funder

the National Natural Science Foundation of China

National Key Research and Development Program of China

National Basic Research Program (973 Program)

National Department Public Benefit Research Foundation

National Science & Technology Pillar Program during the Twelfth Five-year Plan Period

Hunan Provincial Natural Science Foundation of China

Clinical Research Funds of Xiangya Hospital

Central Universities of Central South University

Shanghai Municipal Education Commission-Gaofeng Clinical Medicine

High-level medical personnel of Hunan province

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

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