The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction-Reference-Cited by-同舟云学术

The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction

Published:2019-01-24 Issue:2 Volume:142 Page:391-411
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Chan Felix¹²,Lax Nichola Z²,Voss Caroline Marie³,Aldana Blanca Irene³,Whyte Shuna¹,Jenkins Alistair⁴,Nicholson Claire⁴,Nichols Sophie¹,Tilley Elizabeth¹,Powell Zoe¹,Waagepetersen Helle S³,Davies Ceri H⁵,Turnbull Doug M²,Cunningham Mark O¹⁶

Affiliation:

1. Institute of Neuroscience, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne, UK

2. Wellcome Centre for Mitochondrial Research, Newcastle University, Institute of Neuroscience, The Medical School, Framlington Place, Newcastle upon Tyne, UK

3. Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark

4. Department of Neurosurgery, Royal Victoria Infirmary, Newcastle upon Tyne, UK

5. Neural Pathways DPU, GSK, 11 Biopolis Way, Singapore

6. Discipline of Physiology, School of Medicine, Trinity College Dublin, Dublin 2, Ireland

Abstract

Many patients with mitochondrial disease have neurological symptoms, including drug-refractory epilepsy. Chan et al. develop an in vitro model of mitochondrial epilepsy with face and predictive validity. The model provides mechanistic insights into the role of astrocytes and the GABA-glutamate-glutamine cycle in driving seizure generation.

Funder

EPSRC Industrial CASE Award

Wellcome Trust

MRC Centre for Ageing and Vitality

NIHR

NHS Foundation Trust

Network of European Neuroscience Schools

NENS

University of Copenhagen

Publisher

Oxford University Press (OUP)

Subject