Dopaminergic medication reduces striatal sensitivity to negative outcomes in Parkinson’s disease-Reference-Cited by-同舟云学术

Dopaminergic medication reduces striatal sensitivity to negative outcomes in Parkinson’s disease

Published:2019-10-11 Issue:11 Volume:142 Page:3605-3620
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

McCoy Brónagh¹,Jahfari Sara²³,Engels Gwenda⁴,Knapen Tomas¹²,Theeuwes Jan¹

Affiliation:

1. Department of Experimental and Applied Psychology, Vrije Universiteit, Amsterdam, The Netherlands

2. Spinoza Centre for Neuroimaging, Royal Academy of Sciences, Amsterdam, The Netherlands

3. Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands

4. Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit, Amsterdam, The Netherlands

Abstract

McCoy et al. show that dopaminergic medication in Parkinson’s disease leads to changes in striatal signalling and in behaviour during learning, but that changes are specific to the processing of negative reinforcements. These within-patient changes are predictive of changes in future value-based choice behaviour and striatal responses.

Funder

ERC

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

Link

http://academic.oup.com/brain/article-pdf/142/11/3605/30350410/awz276.pdf

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