A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis-Reference-Cited by-同舟云学术

A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis

Published:2019-10-03 Issue:11 Volume:142 Page:3440-3455
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Nutma Erik¹^ORCID,Stephenson Jodie A¹²,Gorter Rianne P¹,de Bruin Joy¹,Boucherie Deirdre M¹,Donat Cornelius K³,Breur Marjolein¹,van der Valk Paul¹,Matthews Paul M³⁴,Owen David R³,Amor Sandra¹²

Affiliation:

1. Department of Pathology, Amsterdam UMC, Location VUmc, The Netherlands

2. Centre for Neuroscience and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK

3. Department of Brain Sciences, Imperial College London, UK

4. UK Dementia Research Institute, Imperial College London, UK

Abstract

Radioligands targeting the 18 kDa translocator protein (TSPO) are increasingly used to visualise inflammation in the brain. Nutma et al. report that TSPO expression in multiple sclerosis lesions originates mainly from astrocytes and microglia, but is not restricted to cells with a specific pro-inflammatory phenotype.

Funder

UK MS society

Edmond J Safra Foundation

Lily Safra

NIHR

TSPO

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

Link

http://academic.oup.com/brain/article-pdf/142/11/3440/30329922/awz287.pdf