The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target

Author:

Petyuk Vladislav A1,Chang Rui2,Ramirez-Restrepo Manuel3,Beckmann Noam D2,Henrion Marc Y R2,Piehowski Paul D1,Zhu Kuixi2,Wang Sven2,Clarke Jennifer4,Huentelman Matthew J5,Xie Fang1,Andreev Victor6,Engel Anzhelika3,Guettoche Toumy7,Navarro Loida7,De Jager Philip8910,Schneider Julie A11,Morris Christopher M12,McKeith Ian G13,Perry Robert H14,Lovestone Simon15,Woltjer Randall L16,Beach Thomas G17,Sue Lucia I17,Serrano Geidy E17,Lieberman Andrew P18,Albin Roger L1920,Ferrer Isidre21,Mash Deborah C22,Hulette Christine M23,Ervin John F24,Reiman Eric M2526,Hardy John A27,Bennett David A11,Schadt Eric2,Smith Richard D1,Myers Amanda J32829

Affiliation:

1. Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA

2. Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

3. Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA

4. Food Science and Technology Department, University of Nebraska-Lincoln, Lincoln, NE, USA

5. Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA

6. Arbor Research Collaborative for Health, 340 E Huron St # 300, Ann Arbor, MI USA

7. Roche Sequencing, 4300 Hacienda Drive, Pleasanton, CA, USA

8. Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA

9. New York Genome Center, New York NY, USA

10. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

11. Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA

12. Newcastle Brain Tissue Resource, Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PJ, UK

13. NIHR Biomedical Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PJ, UK

14. Neuropathology and Cellular Pathology, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, UK

15. University of Oxford, Medical Sciences Division, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK

16. Neuropathology Core of the Layton Aging and Alzheimer’s Disease Center, Oregon Health and Science University, Portland, OR, USA

17. Banner Sun Health Research Institute, Sun City, AZ, USA

18. Department of Pathology, University of Michigan, Ann Arbor, MI, USA

19. Department of Neurology, University of Michigan, Ann Arbor, MI, USA

20. Geriatrics Research, Education, and Clinical Center, VAAAHS, Ann Arbor, MI, USA

21. Department of Pathology and Experimental Therapeutics, University of Barcelona; CIBERNED; Hospitalet de Llobregat, Spain

22. Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA

23. Department of Pathology, Division of Neuropathology, Duke University Medical Center, Durham, NC, USA

24. Kathleen Price Bryan Brain Bank, Department of Medicine, Division of Neurology, Duke University, Durham, NC, USA

25. The Arizona Alzheimer’s Consortium, Phoenix, Arizona, USA

26. Banner Alzheimer’s Institute, Phoenix, Arizona, USA

27. Department of Molecular Neuroscience and Reta Lila Research Laboratories, University College London Institute of Neurology, London WC1E 6BT, UK

28. Interdepartmental Program in Neuroscience, University of Miami Miller School of Medicine, Miami, FL, USA

29. Interdepartmental Program in Human Genetics and Genomics, University of Miami Miller School of Medicine, Miami, FL, USA

Funder

National Center for Research Resources

National Institute of General Medical Sciences

National Institutes of Health

NIH

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

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