Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration

Author:

Eggers Ruben1,de Winter Fred1,Hoyng Stefan A1,Hoeben Rob C2,Malessy Martijn J A13,Tannemaat Martijn R14,Verhaagen Joost15

Affiliation:

1. Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an institute of the Royal Academy of Arts and Sciences, Amsterdam, The Netherlands

2. Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands

3. Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands

4. Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands

5. Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognition research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands

Funder

Wings for Life Spinal Cord Research Foundation

International Spinal Research Trust

Dwarslaesiefonds

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

Reference83 articles.

1. The GDNF family: signalling, biological functions and therapeutic value;Airaksinen;Nat Rev Neurosci,2002

2. Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration;Al-Majed;J Neurosci,2000

3. Schwann cells transduced with a lentiviral vector encoding Fgf-2 promote motor neuron regeneration following sciatic nerve injury;Allodi;Glia,2014

4. Differential distribution of exogenous BDNF, NGF, and NT-3 in the brain corresponds to the relative abundance and distribution of high-affinity and low-affinity neurotrophin receptors;Anderson;J Comput Neurol,1995

5. c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration;Arthur-Farraj;Neuron,2012

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