Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis-Reference-Cited by-同舟云学术

Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis

Published:2019-09-28 Issue:11 Volume:142 Page:3411-3427
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Herich Sebastian¹,Schneider-Hohendorf Tilman¹^ORCID,Rohlmann Astrid²,Khaleghi Ghadiri Maryam³,Schulte-Mecklenbeck Andreas¹,Zondler Lisa⁴,Janoschka Claudia¹,Ostkamp Patrick¹,Richter Jannis¹,Breuer Johanna¹,Dimitrov Stoyan⁵^ORCID,Rammensee Hans-Georg⁶,Grauer Oliver M¹,Klotz Luisa¹,Gross Catharina C¹,Stummer Walter³,Missler Markus²,Zarbock Alexander⁴,Vestweber Dietmar⁷,Wiendl Heinz¹,Schwab Nicholas¹^ORCID

Affiliation:

1. Department of Neurology with Institute of Translational Neurology, University Hospital Münster, University of Münster, Münster, Germany

2. Institute of Anatomy and Molecular Neurobiology University of Münster, Münster, Germany

3. Department of Neurosurgery, University Hospital Münster, Münster, Germany

4. Department of Anesthesiology, Intensive Care and Pain Medicine, University of Münster, Münster, Germany

5. Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany

6. Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany

7. Max Planck Institute for Molecular Biomedicine, University of Münster, Münster, Germany

Abstract

Specific immune-cell populations patrol the CNS in search of pathogens and tumours. Herich et al. identify CD4+ CCR5high GzmK+ effector-memory cells as a brain-surveilling subpopulation capable of crossing the uninflamed blood-brain barrier, and reveal alterations in this population in HIV+ patients with neurological symptoms and in patients with multiple sclerosis.

Funder

Deutsche Forschungsgemeinschaft

Project B01

Kompetenznetz Multiple Sklerose

Federal Ministry of Education and Research

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

Link

http://academic.oup.com/brain/article-pdf/142/11/3411/30329888/awz301.pdf

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