A year-long immune profile of the systemic response in acute stroke survivors-Reference-Cited by-同舟云学术

A year-long immune profile of the systemic response in acute stroke survivors

Published:2019-03-12 Issue:4 Volume:142 Page:978-991
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Tsai Amy S¹,Berry Kacey²³,Beneyto Maxime M¹,Gaudilliere Dyani⁴,Ganio Edward A¹,Culos Anthony¹,Ghaemi Mohammad S¹,Choisy Benjamin¹,Djebali Karim¹,Einhaus Jakob F¹,Bertrand Basile¹,Tanada Athena¹,Stanley Natalie¹,Fallahzadeh Ramin¹,Baca Quentin¹,Quach Lisa N²³,Osborn Elizabeth²³,Drag Lauren³,Lansberg Maarten G²³,Angst Martin S¹,Gaudilliere Brice¹,Buckwalter Marion S²³⁵,Aghaeepour Nima¹

Affiliation:

1. Department of Anesthesiology, Perioperative and Pain Medicine, Stanford School of Medicine, CA, USA

2. Stanford Stroke Center, Stanford School of Medicine, CA, USA

3. Department of Neurology and Neurological Sciences, Stanford School of Medicine, CA, USA

4. Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, CA, USA

5. Department of Neurosurgery, Stanford School of Medicine, CA, USA

Abstract

Whether the systemic immune response to stroke contributes to long-term disability is unclear. Using deep immune profiling of peripheral blood over a one-year period following ischaemic stroke, Tsai et al. identify three immunological phases characterized by sequential engagement of innate and adaptive immune compartments, which correlate with post-stroke cognitive trajectories.

Funder

NIH

Big Ideas in Neuroscience

Stanford's Wu Tsai Neurosciences Institute

Stroke Collaborative Action Network

Department of Anesthesiology, Perioperative and Pain Medicine at the Stanford School of Medicine

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

Link

http://academic.oup.com/brain/article-pdf/142/4/978/31622458/awz022.pdf