Haemorrhage of human foetal cortex associated with SARS-CoV-2 infection

Author:

Massimo Marco12,Barelli Carlotta12,Moreno Catalina12,Collesi Chiara34,Holloway Rebecca K56789,Crespo Berta10,Zentilin Lorena3ORCID,Williams Anna11ORCID,Miron Veronique E56789,Giacca Mauro3412,Long Katherine R12ORCID

Affiliation:

1. Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London , London , UK

2. MRC Centre for Neurodevelopmental Disorders, King’s College London , London , UK

3. Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB) , 34139 Trieste , Italy

4. Department of Medical, Surgical and Health Sciences, University of Trieste , Trieste , Italy

5. Centre for Discovery Brain Sciences, Chancellor’s Building, The University of Edinburgh , Edinburgh , UK

6. Dementia Research Institute at The University of Edinburgh , Edinburgh , UK

7. Medical Research Council Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh , Edinburgh , UK

8. Barlo Multiple Sclerosis Centre and Keenan Research Institute for Biomedical Science, St. Michael's Hospital , Toronto, Ontario , Canada

9. Department of Immunology, University of Toronto , Toronto, Ontario , Canada

10. Great Ormond Street Institute of Child Health, University College London , London , UK

11. Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh BioQuarter , Edinburgh , UK

12. British Heart Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, King’s College London , London , UK

Abstract

AbstractMaternal viral infection and immune response are known to increase the risk of altered development of the foetal brain. Given the ongoing global pandemic of coronavirus disease 2019 (COVID-19), investigating the impact of SARS-CoV-2 on foetal brain health is of critical importance. Here, we report the presence of SARS-CoV-2 in first and second trimester foetal brain tissue in association with cortical haemorrhages. SARS-CoV-2 spike protein was sparsely detected within progenitors and neurons of the cortex itself, but was abundant in the choroid plexus of haemorrhagic samples. SARS-CoV-2 was also sparsely detected in placenta, amnion and umbilical cord tissues. Cortical haemorrhages were linked to a reduction in blood vessel integrity and an increase in immune cell infiltration into the foetal brain. Our findings indicate that SARS-CoV-2 infection may affect the foetal brain during early gestation and highlight the need for further study of its impact on subsequent neurological development.

Funder

Medical Research Council

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3