Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

Author:

Durante Valentina1,de Iure Antonio12,Loffredo Vittorio34,Vaikath Nishant5,De Risi Maria6,Paciotti Silvia7,Quiroga-Varela Ana1,Chiasserini Davide1,Mellone Manuela8,Mazzocchetti Petra1,Calabrese Valeria12,Campanelli Federica19,Mechelli Alessandro1,Di Filippo Massimiliano1,Ghiglieri Veronica910,Picconi Barbara211,El-Agnaf Omar M.5,De Leonibus Elvira36,Gardoni Fabrizio8,Tozzi Alessandro79,Calabresi Paolo19

Affiliation:

1. Neurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy

2. Laboratory of Experimental Neurophysiology, IRCCS San Raffaele Pisana, Rome, Italy

3. Institute of Cellular Biology and Neurobiology, National Research Council, Monterotondo (Rome), Italy

4. PhD Program in Behavioral Neuroscience, Sapienza University of Rome, Italy

5. Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar

6. Telethon Institute of Genetics and Medicine, Telethon Foundation, Pozzuoli (NA), Italy

7. Department of Experimental Medicine, Section of Physiology and Biochemistry, University of Perugia, Perugia, Italy

8. Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy

9. Laboratory of Neurophysiology, Santa Lucia Foundation, IRCCS, Rome, Italy

10. Department of Philosophy, Human, Social and Educational Sciences, University of Perugia, Perugia, Italy

11. University of San Raffaele, Rome, Italy

Funder

Fondazione Cariplo

MIUR-PRIN

Ricerca Finalizzata

Dipartimento Neuroscienze

Università di Firenze”

AIRAlzh Onlus-COOP Italia

Fresco Parkinson Institute

New York University School of Medicine

Marlene and Paolo Fresco Institute for Parkinson’s and Movement Disorders

Marlene and Paolo Fresco

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

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