Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma-Reference-Cited by-同舟云学术

Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma

Published:2019-10-31 Issue:12 Volume:142 Page:3672-3693
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Iverson Grant L¹²³⁴,Gardner Andrew J⁵⁶,Shultz Sandy R⁷,Solomon Gary S⁸⁹¹⁰,McCrory Paul¹¹,Zafonte Ross¹²⁴,Perry George¹²,Hazrati Lili-Naz¹³,Keene C Dirk¹⁴,Castellani Rudolph J¹⁵¹⁶

Affiliation:

1. Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA

2. Spaulding Rehabilitation Hospital and Spaulding Research Institute, Boston, Massachusetts, USA

3. MassGeneral Hospital for Children™ Sports Concussion Program, Boston, Massachusetts, USA

4. Home Base, A Red Sox Foundation and Massachusetts General Hospital Program, Boston, Massachusetts, USA

5. Hunter New England Local Health District, Sports Concussion Program, University of Newcastle, Callaghan, NSW, Australia

6. Centre for Stroke and Brain Injury, School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia

7. Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, Australia

8. Department of Neurological Surgery, Orthopaedic Surgery and Rehabilitation, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

9. Department of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

10. Vanderbilt Sports Concussion Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

11. The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre - Austin Campus, Heidelberg, Victoria Australia

12. College of Sciences, University of Texas, San Antonio; San Antonio, Texas, USA

13. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

14. Department of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, Washington, USA

15. Department of Pathology, Anatomy and Laboratory Medicine, West Virginia University School of Medicine, Morgantown, USA

16. Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, USA

Abstract

CTE is often conceptualized as a delayed-onset and progressive neurodegenerative disease with unique pathology. However, based on a comprehensive review of the evidence, Iverson et al. argue that CTE pathology cannot be considered inexorably progressive or wholly specific to those who have experienced repetitive neurotrauma.

Funder

Australian Football League

NSW Sporting Injuries Committee, the Brain Foundation

Hunter Medical Research Institute

HMRI

NHMRC Early Career Fellowship

Hunter New England Local Health District, Research, Innovation and Partnerships Health Research & Translation Centre and Clinical Research Fellowship Scheme

University of Newcastle’s Priority Research Centre for Stroke and Brain Injury

NIDILRR

NIH

USARMC

Alzheimer's Association, Semmes Foundation

Henry Jackson Foundation and Allen Institute for Brain Science

Western Michigan University School of Medicine

University of Maryland

Lieber Institute for Brain Development

Canadian Institutes of Health Research

National Institute of Neurological Disorders and Stroke

Publisher