Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease

Author:

Hong Chansik1,Seo Hyemyung2,Kwak Misun1,Jeon Jeha2,Jang Jihoon2,Jeong Eui Man3,Myeong Jongyun1,Hwang Yu Jin4,Ha Kotdaji1,Kang Min Jueng5,Lee Kyu Pil6,Yi Eugene C.5,Kim In-Gyu3,Jeon Ju-Hong1,Ryu Hoon47,So Insuk1

Affiliation:

1. 1 Department of Physiology and Institute of Dermatological Science, Seoul National University College of Medicine, Seoul, 110-799, South Korea

2. 2 Department of Molecular and Life Sciences, Hanyang University, Ansan, 425-791, South Korea

3. 3 Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul, 110-799, South Korea

4. 4 VA Boston Healthcare System, Department of Neurology and Boston University Alzheimer’s Disease Centre, Boston University School of Medicine, Boston, MA 02118, USA

5. 5 Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University College of Medicine or Pharmacy, Seoul, 110-799, South Korea

6. 6 Department of Physiology, College of Veterinary Medicine, Chungnam National University, Daejeon, 305-764, South Korea

7. 7 Centre for Neuromedicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, 136-791, South Korea

Funder

NIH

National Research Foundation of Korea

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

Reference53 articles.

1. Differential electrophysiological changes in striatal output neuronsin Huntington’s disease;Andre;J. Neurosci,2011

2. Cell death in the nervous system;Bredesen;Nature,2006

3. Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release;Choo;Hum Mol Genet,2004

4. Reversible and irreversible protein glutathionylation by respiratory substrates;Cooper;Expert Opin Drug Metab Toxicol,2011

5. Oxidative stress, glutamate, and neurodegenerative disorders;Coyle;Science,1993

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