Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor-Reference-Cited by-同舟云学术

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Published:2019-10-10 Issue:11 Volume:142 Page:3636-3654
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Carvalho Kevin¹,Faivre Emilie¹,Pietrowski Marie J²,Marques Xavier³,Gomez-Murcia Victoria¹,Deleau Aude¹,Huin Vincent¹^ORCID,Hansen Jan N²,Kozlov Stanislav²,Danis Clément¹⁴,Temido-Ferreira Mariana⁵,Coelho Joana E⁵,Mériaux Céline¹,Eddarkaoui Sabiha¹,Gras Stéphanie Le⁶,Dumoulin Mélanie⁷,Cellai Lucrezia¹,Landrieu Isabelle⁴,Chern Yijuang⁸,Hamdane Malika¹,Buée Luc¹,Boutillier Anne-Laurence⁹,Levi Sabine³,Halle Annett²¹⁰,Lopes Luisa V⁵,Blum David¹^ORCID,

Affiliation:

1. University of Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc, LabEx DISTALZ, F Lille, France

2. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

3. Institut du Fer à Moulin, Inserm UMR-S 1270, Sorbonne Université, F, Paris, France

4. University of Lille, CNRS UMR8576, Unité de Glycobiologie Structurale et Fonctionnelle, LabEx DISTALZ, Lille, F Lille, France

5. Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Universidade de Lisboa, Lisbon, Portugal

6. CNRS, Inserm, UMR 7104, GenomEast Platform, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, F Illkirch, France

7. University of Lille, F Lille, France

8. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

9. Laboratoire de Neuroscience Cognitives et Adaptatives (LNCA), CNRS UMR 7364, Université de Strasbourg, F Strasbourg, France

10. Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany

Abstract

See Cunha (doi:10.1093/brain/awz335) for a scientific commentary on this article. Carvalho et al. provide clues to the onset of immune dysregulation underlying early synaptic loss in Alzheimer’s disease and tauopathies, by linking overactivation of adenosine A2A receptors in tau pathology to a particular microglial signature (upregulation of C1q and TREM2) allied to the loss of glutamatergic synapses and cognitive deficits.

Funder

PARTEN-AIRR

COGNADORA

ADORATAU

Programs d’Investissements d’Avenir LabEx

DISTALZ

ANR

ADORASTrAU

Fondation pour la Recherche Médicale

France Alzheimer/Fondation de France

Fondation Vaincre Alzheimer

Fondation Plan Alzheimer

Région Hauts-de-France

Fondation pour la Recherche Médicale et Fondation pour la Recherche sur le Cerveau

CNRS

Fundaçao para a Ciência e Tecnologia

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

Link

http://academic.oup.com/brain/article-pdf/142/11/3636/30333839/awz288.pdf

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