A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction

Author:

Lopez Ana12,Lee Suzee E.3,Wojta Kevin4,Ramos Eliana Marisa4,Klein Eric4,Chen Jason4,Boxer Adam L.3,Gorno-Tempini Maria Luisa3,Geschwind Daniel H.4,Schlotawa Lars12,Ogryzko Nikolay V.5,Bigio Eileen H.6,Rogalski Emily6,Weintraub Sandra6,Mesulam Marsel M.6,Fleming Angeleen12,Coppola Giovanni4,Miller Bruce L.3,Rubinsztein David C.1,

Affiliation:

1. Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0XY, UK

2. Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK

3. Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA

4. Department of Psychiatry and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA

5. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK

6. Cognitive Neurology and Alzheimer’s Disease Center, Northwestern University, Chicago, IL 60611, USA

Funder

National Institutes of Health

National Institute on Aging

Wellcome Trust

Tau consortium

Alzheimer’s Research UK (DCR) Wellcome Trust

Wellcome Trust Strategic Grant to Cambridge Institute for Medical Research

NIHR Biomedical Research Unit in Dementia at Addenbrooke’s Hospital, the John Douglas French Alzheimer’s Foundation for funding

DFG fellowship, N.V.O. is funded by BBSRC project

National Cell Repository for Alzheimer’s Disease (NCRAD)

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

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