Increased translation as a novel pathogenic mechanism in Huntington’s disease

Abstract

See Brouillet and Merienne (doi:10.1093/brain/awz274) for a scientific commentary on this article.Creus-Muncunill et al. report that protein translation is altered in the striatum of Huntington’s disease mouse models, with upregulated expression of proteins from ribosomal and oxidative phosphorylation pathways. Pharmacological normalization of protein translation in R6/1 mice ameliorates motor disturbances and normalizes ribosomal content in the striatum.