The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes-Reference-Cited by-同舟云学术

The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes

Published:2019-09-09 Issue:10 Volume:142 Page:3230-3242
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Jack Clifford R¹^ORCID,Wiste Heather J²,Botha Hugo³^ORCID,Weigand Stephen D²,Therneau Terry M²,Knopman David S³,Graff-Radford Jonathan³,Jones David T¹³,Ferman Tanis J⁴,Boeve Bradley F³^ORCID,Kantarci Kejal¹,Lowe Val J⁵,Vemuri Prashanthi¹,Mielke Michelle M⁶,Fields Julie A⁷,Machulda Mary M⁷,Schwarz Christopher G¹,Senjem Matthew L¹,Gunter Jeffrey L¹,Petersen Ronald C³

Affiliation:

1. Department of Radiology, Mayo Clinic, Rochester, MN, USA

2. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA

3. Department of Neurology, Mayo Clinic, Rochester, MN, USA

4. Department of Psychology, Mayo Clinic, Jacksonville, FL, USA

5. Department of Nuclear Medicine, Mayo Clinic, Rochester, MN, USA

6. Department of Epidemiology, Mayo Clinic, Rochester, MN, USA

7. Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA

Abstract

See Gordon and Tijms (doi:10.1093/brain/awz278) for a scientific commentary on this article. Jack et al. examine relationships between the bivariate distribution of β-amyloid and tau on PET and established neurocognitive clinical syndromes. Amyloidosis appears to be required for high levels of 3R/4R tau deposition. Whereas abnormal amyloid PET is compatible with normal cognition, highly abnormal tau PET is not.

Funder

National Institutes of Health

GHR Foundation

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

Link

http://academic.oup.com/brain/advance-article-pdf/doi/10.1093/brain/awz268/29848942/awz268.pdf

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