Association of variants inHTRA1andNOTCH3with MRI-defined extremes of cerebral small vessel disease in older subjects

Author:

Mishra Aniket1,Chauhan Ganesh12,Violleau Marie-Helene1,Vojinovic Dina3,Jian Xueqiu4,Bis Joshua C5,Li Shuo6,Saba Yasaman7,Grenier-Boley Benjamin8910,Yang Qiong611,Bartz Traci M12,Hofer Edith1314,Soumaré Aïcha1,Peng Fen4,Duperron Marie-Gabrielle1,Foglio Mario15,Mosley Thomas H1617,Schmidt Reinhold13,Psaty Bruce M18192021,Launer Lenore J22,Boerwinkle Eric4,Zhu Yicheng23,Mazoyer Bernard24,Lathrop Mark15,Bellenguez Celine8910,Van Duijn Cornelia M325,Ikram M Arfan326,Schmidt Helena7,Longstreth W T27,Fornage Myriam4,Seshadri Sudha2811,Joutel Anne29,Tzourio Christophe130,Debette Stephanie11131

Affiliation:

1. University of Bordeaux, Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, F-33000 Bordeaux, France

2. Centre for Brain Research, Indian Institute of Science, Bangalore, India

3. Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

4. The University of Texas Health Science Center at Houston, Houston, TX, USA

5. Department of Biostatistics, University of Washington, Seattle, WA, USA

6. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA

7. Gottfried Schatz Research Center, Department of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria

8. Inserm, U1167, RID-AGE - Risk factors and molecular determinants of aging-related diseases, F-59000 Lille, France

9. Institut Pasteur de Lille, F-59000 Lille, France

10. Univ. Lille, U1167 - Excellence Laboratory LabEx DISTALZ, F-59000 Lille, France

11. Department of Neurology, Boston University School of Medicine, Boston, MA, USA

12. Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA

13. Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria

14. Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria

15. University of McGill Genome Center, Montreal, Canada

16. Division of Geriatrics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA

17. Memory Impairment and Neurodegenerative Dementia Center, University of Mississippi Medical Center, Jackson, MS, USA

18. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA

19. Department of Epidemiology, University of Washington, Seattle, WA, USA

20. Department of Health Services, University of Washington, Seattle, WA, USA

21. Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA

22. Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA

23. Department of Neurology, Peking Union Medical College Hospital, Beijing, China

24. University of Bordeaux, Institut des Maladies Neurodégénératives, CNRS-CEA UMR 5293, France

25. Nuffield Department of Population Health, University of Oxford, Oxford, UK

26. Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

27. Department of Neurology and Department of Epidemiology, University of Washington, Seattle, WA, USA

28. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, Texas, USA

29. Institute of Psychiatry and Neurosciences of Paris, Inserm, University Paris Descartes, DHU NeuroVasc, Sorbonne Paris Cité, Paris, France

30. CHU de Bordeaux, Pole de santé publique, Service d’information médicale, F-33000 Bordeaux, France

31. CHU de Bordeaux, Department of Neurology, F-33000 Bordeaux, France

Funder

Fondation Leducq

Transatlantic Network of Excellence on the Pathogenesis of SVD of the Brain

EU Joint Programme -Neurodegenerative Disease Research

JPND

National Health and Medical Research Council

Federal Ministry of Science, Research and Economy

Canada, Canadian Institutes of Health Research

France, French National Research Agency

Germany, Federal Ministry of Education and Research

The Netherlands Organisation for Health Research and Development

Medical Research Council

European Union’s Horizon 2020

European Research Council

ERC

Bordeaux Bioinformatics Center

Université de Bordeaux

Fondation Claude Pompidou

French National Research Agency

National Foundation for Alzheimer’s

National Heart, Lung, and Blood Institute

NHLBI

National Human Genome Research Institute

National Institutes of Health

NIH

NIH Roadmap for Medical Research

Cardiovascular Health Study

CHS

National Institute of Neurological Disorders and Stroke

NINDS

National Institute on Aging

NIA

National Center for Advancing Translational Sciences

CTSI

National Institute of Diabetes and Digestive

Kidney Disease Diabetes Research Center

DRC

Southern California Diabetes Endocrinology Research Center

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

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