Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice-Reference-Cited by-同舟云学术

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

Published:2017-04-19 Issue:6 Volume:140 Page:1768-1783
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Halliday Mark¹,Radford Helois¹,Zents Karlijn A. M.²,Molloy Collin¹,Moreno Julie A.¹,Verity Nicholas C.¹,Smith Ewan¹,Ortori Catharine A.³,Barrett David A.³,Bushell Martin¹,Mallucci Giovanna R.¹²

Affiliation:

1. 1 MRC Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK

2. 2 Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0AH, UK

3. 3 Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK

Funder

Medical Research Council, UK

Alzheimer’s Society & Alzheimer’s Drug Discovery Foundation

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

Link

http://academic.oup.com/brain/article-pdf/140/6/1768/24175041/awx074.pdf

Reference49 articles.

1. Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease;Celardo;Cell Death Dis,2016

2. PERK mediates eIF2 alpha phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer’s disease;Devi;Neurobiol Aging,2014

3. Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes;Dinkova-Kostova;Carcinogenesis,1999

4. Proteomic analysis of proteins altered by dibenzoylmethane in human prostatic cancer LNCaP cells;Frazier;Proteomics,2004

5. Modulating the unfolded protein response to prevent neurodegeneration and enhance memory;Halliday;Neuropathol Appl Neurobiol,2015

Cited by 229 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Lithium: effects in animal models of vanishing white matter are not promising;Frontiers in Neuroscience;2024-01-30

2. Downregulation of ATF-4 Attenuates the Endoplasmic Reticulum Stress–Mediated Neuroinflammation and Cognitive Impairment in Experimentally Induced Alzheimer’s Disease Model;Molecular Neurobiology;2023-12-30

3. Trazodone attenuates the neuroinflammation signaling mechanism and restores the activity of BACE 1 and ChAT in scopolamine-induced AD-like symptoms in male wistar rats;2023-12-21

4. Early and Late Chaperone Intervention Therapy Boosts XBP1s and ADAM10, Restores Proteostasis, and Rescues Learning in Alzheimer’s Disease Mice;Aging Biology;2023-12-16

5. Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing;International Journal of Molecular Sciences;2023-11-27