Non-motor outcomes depend on location of neurostimulation in Parkinson’s disease

Author:

Petry-Schmelzer Jan Niklas1,Krause Max1,Dembek Till A1,Horn Andreas2ORCID,Evans Julian3,Ashkan Keyoumars4,Rizos Alexandra4,Silverdale Monty3,Schumacher Wibke1,Sack Carolin1,Loehrer Philipp A5,Fink Gereon R16,Fonoff Erich T7,Martinez-Martin Pablo8,Antonini Angelo9,Barbe Michael T1,Visser-Vandewalle Veerle10,Ray-Chaudhuri K411,Timmermann Lars15,Dafsari Haidar S14,Ray-Chaudhuri Kallol,Antonini Angelo,Martinez-Martin Pablo,Odin Per,Schrag Anette,Weintraub Daniel,Barone Paolo,Brooks David J,Brown Richard G,Jenner Peter,Jeon B,Lyons Kelly,Pavese Nicola,Politis Marios,Postuma Ronald B,Schapira Anthony,Stocchi Fabrizio,Timmermann Lars,Tsuboi Yoshio,Rizos Alexandra,Sauerbier Anna,

Affiliation:

1. University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Cologne, Germany

2. Department of Neurology, Charité – University Medicine Berlin, Berlin, Germany

3. Department of Neurology and Neurosurgery, Salford Royal Foundation Thrust, Greater Manchester, UK

4. National Parkinson Foundation Centre of Excellence, King’s College Hospital, London, UK

5. Department of Neurology, University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany

6. Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich, Jülich, Germany

7. Division of Functional Neurosurgery of Institute of Psychiatry, Department of Neurology, University of São Paulo Medical School, São Paulo, Brazil

8. National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain

9. Department of Neuroscience, University of Padua, Padua, Italy

10. University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Stereotaxy and Functional Neurosurgery, Cologne, Germany

11. The Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK

Abstract

Deep brain stimulation of the subthalamic nucleus improves non-motor symptoms in Parkinson’s disease, but with considerable inter-individual variability. Petry-Schmelzer et al. show that neurostimulation in specific subregions of the subthalamic nucleus has differential effects on mood/apathy, attention/memory and sleep-related outcomes. Neurostimulation could thus be tailored to patients’ individual non-motor profiles.

Funder

German Research Foundation

KFO

Koln Fortune Program

Konrad-Adenauer Foundation

Prof. Klaus Thiemann Foundation

Felgenhauer Foundation

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

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