Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke

Author:

Phuah Chia-Ling121,Dave Tushar3,Malik Rainer4,Raffeld Miriam R1,Ayres Alison M15,Goldstein Joshua N6,Viswanathan Anand7,Greenberg Steven M5,Jagiella Jeremiasz M8,Hansen Björn M910,Norrving Bo910,Jimenez-Conde Jordi1112,Roquer Jaume1112,Pichler Alexander13,Enzinger Christian1314,Montaner Joan15,Fernandez-Cadenas Israel1516,Lindgren Arne910,Slowik Agnieszka8,Schmidt Reinhold13,Biffi Alessandro1151718,Rost Natalia5,Langefeld Carl D19,Markus Hugh S20,Mitchell Braxton D21,Worrall Brad B2223,Kittner Steven J2425,Woo Daniel26,Dichgans Martin427,Rosand Jonathan1215,Anderson Christopher D1275, , ,

Affiliation:

1. Center for Human Genetic Research, Massachusetts General Hospital (MGH), Boston, MA, USA

2. Division of Neurocritical Care and Emergency Neurology, Department of Neurology, MGH, Boston, MA, USA

3. Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, USA

4. Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany

5. J. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA

6. Department of Emergency Medicine, MGH, Boston, MA, USA

7. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

8. Department of Neurology, Jagiellonian University Medical College, Krakow, Poland

9. Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden

10. Department of Neurology and Rehabilitation Medicine, Neurology, Skåne University Hospital, Lund, Sweden

11. Neurovascular Research Unit, Department of Neurology, Institut Municipal d’Investigacio´ Medica–Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain

12. Program in Inflammation and Cardiovascular Disorders, Institut Municipal d’Investigacio´ Medica–Hospital del Mar, Universitat Autonoma de Barcelona, Barcelona, Spain

13. Department of Neurology, Medical University of Graz, Austria

14. Division of Neuroradiology, Department of Radiology, Medical University of Graz, Austria

15. Neurovascular Research Laboratory and Neurovascular Unit, Institut de Recerca, Hospital Vall d’Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain

16. Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mutua Terrassa, Mutua de Terrassa Hospital, Terrassa, Spain

17. Division of Behavioral Neurology, Department of Neurology, MGH, Boston, MA, USA

18. Division of Neuropsychiatry, Department of Psychiatry, MGH, Boston, MA, USA

19. Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, USA

20. Department of Clinical Neurosciences, University of Cambridge, UK

21. Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA

22. Department of Neurology, University of Virginia, Charlottesville, VA, USA

23. Department of Public Health Science, University of Virginia, Charlottesville, VA, USA

24. Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA

25. Department of Neurology, Veterans Affairs Medical Center, Baltimore, MD, USA

26. University of Cincinnati College of Medicine, Cincinnati, OH, USA

27. German Center for Neurodegenerative Diseases (DZNE) and Munich Cluster for Systems Neurology (SyNergy), Germany

Funder

National Institutes of Health

DFG

Fondation Leducq

Instituto de Salud Carlos III

Lund University

Swedish Stroke Association

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

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