Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke

Author:

Mao Leilei123,Li Peiying14,Zhu Wen1,Cai Wei1,Liu Zongjian5,Wang Yanling5,Luo Wenli6,Stetler Ruth A.12,Leak Rehana K.7,Yu Weifeng4,Gao Yanqin2,Chen Jun12,Chen Gang8,Hu Xiaoming125

Affiliation:

1. Pittsburgh Institute of Brain Disorders and Recovery and Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA

2. State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences, Fudan University, Shanghai 200032, China

3. Life Science Research Centre of Taishan Medical University, Taishan 271016, Shandong, China

4. Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

5. China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing 100010, China

6. AstraZeneca Pharmaceutical Company, Waltham, Massachusetts 02452, USA

7. Division of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA

8. Department of Neurosurgery, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China

Funder

National Institutes of Health

Shanghai Natural Science Foundation

Beijing Natural Science Foundation

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

Reference51 articles.

1. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats;Asahi;J Cereb Blood Flow Metab,2000

2. Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients;Battaglia;J Immunol,2006

3. Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia;Brea;J Cell Mol Med,2014

4. Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model;Campos;Stroke,2013

5. Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury;Cao;J Neurosci,2007

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