Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study

Author:

Whelan Christopher D12ORCID,Altmann Andre3,Botía Juan A4,Jahanshad Neda1,Hibar Derrek P1,Absil Julie5,Alhusaini Saud26,Alvim Marina K M7,Auvinen Pia89,Bartolini Emanuele1011,Bergo Felipe P G7,Bernardes Tauana7,Blackmon Karen1213,Braga Barbara7,Caligiuri Maria Eugenia14,Calvo Anna15,Carr Sarah J16,Chen Jian17,Chen Shuai1819,Cherubini Andrea14,David Philippe5,Domin Martin20,Foley Sonya21,França Wendy7,Haaker Gerrit2223,Isaev Dmitry1,Keller Simon S24,Kotikalapudi Raviteja2526,Kowalczyk Magdalena A27,Kuzniecky Ruben12,Langner Soenke20,Lenge Matteo10,Leyden Kelly M2829,Liu Min30,Loi Richard Q2829,Martin Pascal25,Mascalchi Mario3132,Morita Marcia E7,Pariente Jose C15,Rodríguez-Cruces Raul33,Rummel Christian34,Saavalainen Taavi935,Semmelroch Mira K27,Severino Mariasavina36,Thomas Rhys H3738,Tondelli Manuela39,Tortora Domenico36,Vaudano Anna Elisabetta39,Vivash Lucy4041,von Podewils Felix42,Wagner Jan4344,Weber Bernd4345,Yao Yi46,Yasuda Clarissa L7,Zhang Guohao47,Bargalló Nuria1548,Bender Benjamin26,Bernasconi Neda30,Bernasconi Andrea30,Bernhardt Boris C3049,Blümcke Ingmar23,Carlson Chad1250,Cavalleri Gianpiero L251,Cendes Fernando7,Concha Luis33,Delanty Norman25152,Depondt Chantal53,Devinsky Orrin12,Doherty Colin P5154,Focke Niels K2555,Gambardella Antonio1456,Guerrini Renzo1011,Hamandi Khalid3738,Jackson Graeme D2757,Kälviäinen Reetta89,Kochunov Peter58,Kwan Patrick41,Labate Angelo1456,McDonald Carrie R2829,Meletti Stefano39,O'Brien Terence J4159,Ourselin Sebastien3,Richardson Mark P1660,Striano Pasquale61,Thesen Thomas1213,Wiest Roland34,Zhang Junsong1819,Vezzani Annamaria62,Ryten Mina463,Thompson Paul M1,Sisodiya Sanjay M6465

Affiliation:

1. Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, California, USA

2. Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

3. Translational Imaging Group, Centre for Medical Image Computing, University College London, London, UK

4. Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK

5. Department of Radiology, Hôpital Erasme, Universite Libre de Bruxelles, Brussels 1070, Belgium

6. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

7. Department of Neurology, University of Campinas, Campinas, Brazil

8. Epilepsy Center, Department of Neurology, Kuopio University, Kuopio, Finland

9. Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland

10. Pediatric Neurology Unit, Children’s Hospital A. Meyer-University of Florence, Italy

11. IRCCS Stella Maris Foundation, Pisa, Italy

12. Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, USA

13. Department of Physiology, Neuroscience and Behavioral Science, St. George’s University, Grenada, West Indies

14. Institute of Molecular Bioimaging and Physiology of the National Research Council (IBFM-CNR), Catanzaro, Italy

15. Magnetic Resonance Image Core Facility, IDIBAPS, Barcelona, Spain

16. Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK

17. Department of Computer Science and Engineering, The Ohio State University, USA

18. Cognitive Science Department, Xiamen University, Xiamen, China

19. Fujian Key Laboratory of the Brain-like Intelligent Systems, China

20. Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany

21. Cardiff University Brain Research Imaging Centre, School of Psychology, Wales, UK

22. Department of Neurosurgery, University Hospital, Freiburg, Germany

23. Department of Neuropathology, University Hospital Erlangen, Germany

24. Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, UK

25. Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

26. Department of Diagnostic and Interventional Neuroradiology, University of Tübingen, Tübingen, Germany

27. The Florey Institute of Neuroscience and Mental Health, Austin Campus, Melbourne, VIC, Australia

28. Multimodal Imaging Laboratory, University of California San Diego, San Diego, California, USA

29. Department of Psychiatry, University of California San Diego, San Diego, California, USA

30. Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital, Mcgill University, Montreal, Quebec, Canada

31. Neuroradiology Unit, Children's Hospital A. Meyer, Florence, Italy

32. “Mario Serio” Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy

33. Instituto de Neurobiología, Universidad Nacional Autónoma de México. Querétaro, Querétaro, México

34. Support Center for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland

35. Central Finland Central Hospital, Medical Imaging Unit, Jyväskylä, Finland

36. Neuroradiology Unit, Department of Head and Neck and Neurosciences, Istituto Giannina Gaslini, Genova, Italy

37. Institute of Psychological Medicine and Clinical Neurosciences, Hadyn Ellis Building, Maindy Road, Cardiff, UK

38. Department of Neurology, University Hospital of Wales, Cardiff, UK

39. Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, NOCSE Hospital, Modena, Italy

40. Melbourne Brain Centre, Department of Medicine, University of Melbourne, Parkville, VIC, 3052, Australia

41. Department of Neurology, Royal Melbourne Hospital, Parkville, 3050, Australia

42. Department of Neurology, University Medicine Greifswald, Greifswald, Germany

43. Department of Epileptology, University Hospital Bonn, Bonn, Germany

44. Department of Neurology, Philips University of Marburg, Marburg Germany

45. Department of Neurocognition / Imaging, Life&Brain Research Centre, Bonn, Germany

46. The Affiliated Chenggong Hospital of Xiamen University, Xiamen, China

47. Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, USA

48. Centre de Diagnostic Per la Imatge (CDIC), Hospital Clinic, Barcelona, Spain

49. Multimodal Imaging and Connectome Analysis Lab, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada

50. Medical College of Wisconsin, Department of Neurology, Milwaukee, WI, USA

51. FutureNeuro Research Centre, RCSI, Dublin, Ireland

52. Division of Neurology, Beaumont Hospital, Dublin 9, Ireland

53. Department of Neurology, Hôpital Erasme, Universite Libre de Bruxelles, Brussels 1070, Belgium

54. Neurology Department, St. James’s Hospital, Dublin 8, Ireland

55. Department of Clinical Neurophysiology, University Medicine Göttingen, Göttingen, Germany

56. Institute of Neurology, University “Magna Græcia”, Catanzaro, Italy

57. Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia

58. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Maryland, USA

59. Department of Medicine, University of Melbourne, Parkville, VIC, 3052, Australia

60. Department of Neurology, King’s College Hospital, London, UK

61. Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genova, Italy

62. Dept of Neuroscience, Mario Negri Institute for Pharmacological Research, Via G. La Masa 19, 20156 Milano, Italy

63. Department of Medical and Molecular Genetics, King's College London, London SE1 9RT, UK

64. Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK

65. Chalfont Centre for Epilepsy, Bucks, UK

Funder

National Institutes of Health

National Institute of Neurological Disorders and Stroke

Canadian Institutes of Health Research

FAPESP

UNAM

Kuopio University Hospital

Swiss National Science Foundation

National Science Foundation

Medical Research Council

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

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