Deep brain stimulation induced normalization of the human functional connectome in Parkinson’s disease-Reference-Cited by-同舟云学术

Deep brain stimulation induced normalization of the human functional connectome in Parkinson’s disease

Published:2019-08-14 Issue:10 Volume:142 Page:3129-3143
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Horn Andreas¹^ORCID,Wenzel Gregor¹,Irmen Friederike¹²^ORCID,Huebl Julius¹,Li Ningfei¹^ORCID,Neumann Wolf-Julian¹³^ORCID,Krause Patricia¹,Bohner Georg³,Scheel Michael³,Kühn Andrea A¹²⁴

Affiliation:

1. Department of Neurology, Movement Disorders and Neuromodulation Section, Charité – University Medicine Berlin, Berlin, Germany

2. Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany

3. Department of Neuroradiology, Charité – University Medicine Berlin, Berlin, Germany

4. Exzellenzcluster NeuroCure, Charité – Universitätsmedizin Berlin, Berlin, Germany

Abstract

Deep brain stimulation has local effects on the target structure, but also global effects via distributed brain networks. Horn et al. show that modulating the activity of the subthalamic nucleus in patients with Parkinson’s disease normalizes signatures of widespread network connectivity towards those found in healthy controls.

Funder

DFG

Emmy Noether

Parkinson’s Progression Markers Initiative

PPMI

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

Link

http://academic.oup.com/brain/advance-article-pdf/doi/10.1093/brain/awz239/29162250/awz239.pdf

Reference83 articles.