More than 185 CAG repeats: a point of no return in Huntington’s disease biology-Reference-Cited by-同舟云学术

More than 185 CAG repeats: a point of no return in Huntington’s disease biology

Published:2024-04-08 Issue:5 Volume:147 Page:1601-1603
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Belgrad Jillian¹^ORCID,Khvorova Anastasia¹^ORCID

Affiliation:

1. RNA Therapeutics Institute, University of Massachusetts Chan Medical School , Worcester, MA , USA

Abstract

This scientific commentary refers to ‘A CAG repeat threshold for therapeutics targeting somatic instability in Huntington’s disease’ by Aldous et al. (https://doi.org/10.1093/brain/awae063).

Funder

NIH

NINDS

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/brain/advance-article-pdf/doi/10.1093/brain/awae105/57311315/awae105.pdf

Reference10 articles.

1. CAG repeat not polyglutamine length determines timing of Huntington's disease onset;Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium. Electronic address: gusella@helix.mgh.harvard.edu; Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium;Cell,2019

2. Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset;Swami;Hum Mol Genet,2009

3. Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum;Mätlik;Nat Genet.,2024

4. The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients;Neueder;Sci Rep,2017

5. A CAG repeat threshold for therapeutics targeting somatic instability in Huntington’s disease;Aldous;Brain,2024

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