Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus-Reference-Cited by-同舟云学术

Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus

Published:2019-09-23 Issue:11 Volume:142 Page:3482-3501
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Burman Richard J¹²³^ORCID,Selfe Joshua S¹,Lee John Hamin¹,van den Berg Maurits¹,Calin Alexandru³^ORCID,Codadu Neela K⁴^ORCID,Wright Rebecca³,Newey Sarah E³^ORCID,Parrish R Ryley⁴^ORCID,Katz Arieh A⁵,Wilmshurst Jo M²^ORCID,Akerman Colin J³^ORCID,Trevelyan Andrew J⁴^ORCID,Raimondo Joseph V¹^ORCID

Affiliation:

1. Division of Cell Biology, Department of Human Biology, Neuroscience Institute and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

2. Department of Paediatric Neurology, Red Cross War Memorial Children's Hospital, Neuroscience Institute, University of Cape Town, Cape Town, South Africa

3. Department of Pharmacology, University of Oxford, Oxford, UK

4. Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne, NE24HH, UK

5. Division of Medical Biochemistry, Department of Integrated Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

Abstract

Benzodiazepine-resistant status epilepticus is an ongoing clinical challenge. Burman et al. show that longer seizure duration is a useful clinical indicator of benzodiazepine resistance, and that resistance is caused by changes in GABAA receptor-mediated synaptic transmission. The findings could help optimise current management protocols.

Funder

National Research Foundation

Ada and Bertie Levenstein Trust

Mandela Rhodes Foundation

Medical Research Council of South Africa

ERC

Royal Society Newton Advanced Fellowship

University of Cape Town

Blue Brain Project

National Research Foundation of South Africa

Wellcome Trust

FLAIR Fellowship Programme