Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers

Author:

Zhao Ye123,Perera Gayathri13,Takahashi-Fujigasaki Junko4,Mash Deborah C5,Vonsattel Jean Paul G6,Uchino Akiko4,Hasegawa Kazuko7,Jeremy Nichols R8,Holton Janice L9,Murayama Shigeo4,Dzamko Nicolas123,Halliday Glenda M123

Affiliation:

1. Brain and Mind Centre, Sydney Medical School, University of Sydney, Camperdown, 2050, Australia

2. School of Medical Sciences, University of NSW, Kensington, 2033, Australia

3. Neuroscience Research Australia, Randwick, 2031, Australia

4. Department of Neuropathology, Brain Bank for Aging Research, Tokyo Metropolitan Geriatric0 Hospital and Institute of Gerontology, Tokyo, 173-0015, Japan

5. University of Miami Brain Endowment Bank™, University of Miami Miller School of Medicine, Miami, Florida, 33136, USA

6. New York Brain Bank, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, 10032, USA

7. Department of Neurology, Sagamihara National Hospital, Kangawa, 252-0315, Japan

8. Parkinson’s Institute and Clinical Center, Sunnyvale, California, 94085, USA

9. Queen Square Brain Bank, UCL Institute of Neurology, University College London, London, WC1N 1PJ, UK

Funder

National Institutes of Health

National Institute of Mental Health

National Institute of Neurological Disorders and Stroke

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

Reference37 articles.

1. LRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectives;Atashrazm;Clin Pharmacol,2016

2. The significance of GBA for Parkinson's disease;Brockmann;J Inherit Metab Dis,2014

3. The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease;Cookson;Nat Rev Neurosci,2010

4. Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies;Davies;Biochem J,2013

5. Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue;Devine;PLoS One,2011

Cited by 37 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Role of the Insulin-like Growth Factor System in Neurodegenerative Disease;International Journal of Molecular Sciences;2024-04-20

2. Lysosomal storage, impaired autophagy and innate immunity in Gaucher and Parkinson's diseases: insights for drug discovery;Philosophical Transactions of the Royal Society B: Biological Sciences;2024-02-19

3. Retromer-dependent lysosomal stress in Parkinson's disease;Philosophical Transactions of the Royal Society B: Biological Sciences;2024-02-19

4. OXR1 maintains the retromer to delay brain aging under dietary restriction;Nature Communications;2024-01-11

5. ATP13A2 (PARK9) and basal ganglia function;Frontiers in Neurology;2024-01-05

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3