1. Department of Neurology, Centro Hospitalar Universitário do Porto (CHUPorto) , 4099-001 Porto , Portugal
2. Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto , 4050-313 Porto , Portugal
3. Institute for Research and Innovation in Health (i3s), University of Porto , 4200-135 Porto , Portugal
4. Department of Neurology, Kiel University , 24118 Kiel , Germany