An anti-amyloid therapy works for Alzheimer’s disease: why has it taken so long and what is next?
Author:
Affiliation:
1. Reta Lilla Weston Research Laboratories, UCL Institute of Neurology , London, WC1N 3BG , UK
2. Department of Neurodegenerative Disease, UCL Institute of Neurology , London, WC1N 3BG , UK
Abstract
Funder
Dolby Foundation
UCL/UCLH Biomedical Research
UCL Dementia Research Institute
Publisher
Oxford University Press (OUP)
Subject
Neurology (clinical)
Link
https://academic.oup.com/brain/advance-article-pdf/doi/10.1093/brain/awad049/49592604/awad049.pdf
Reference14 articles.
1. Lecanemab in early Alzheimer's disease;van Dyck;N Engl J Med,2022
2. The amyloid hypothesis of Alzheimer's disease at 25 years;Selkoe;EMBO Mol Med,2016
3. Two randomized phase 3 studies of aducanumab in early Alzheimer's disease;Budd Haeberlein;J Prev Alzheimers Dis,2022
4. The amyloid hypothesis in Alzheimer disease: New insights from new therapeutics;Karran;Nat Rev Drug Discov,2022
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