LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory

Author:

Petit-Pedrol Mar1,Sell Josefine2,Planagumà Jesús1,Mannara Francesco1,Radosevic Marija1,Haselmann Holger23,Ceanga Mihai2,Sabater Lidia1,Spatola Marianna14,Soto David15,Gasull Xavier15,Dalmau Josep1678,Geis Christian23

Affiliation:

1. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain

2. Hans-Berger Department of Neurology, Jena University Hospital, Jena, Germany

3. Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany

4. University of Lausanne (UNIL), Lausanne, Switzerland

5. Laboratori de Neurofisiologia, Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain

6. Department of Neurology, University of Pennsylvania, Philadelphia, USA

7. Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER), Valencia, Spain

8. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

Funder

Deutsche Forschungsgemeinschaft

IZKF

CSCC Jena

Instituto Carlos III/FEDER

Fondation de l’Université de Lausanne et Centre Hospitalier Universitaire Vaudois (UNIL/CHUV), Lausanne, Switzerland

NIH

Ministerio de Economia, Industria y Competitividad, Spain

AGAUR

CERCA Programme / Generalitat de Catalunya

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

Reference41 articles.

1. Anti-LGI1-associated cognitive impairment: presentation and long-term outcome;Arino;Neurology,2016

2. LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development;Boillot;Sci Rep,2016

3. Genetic and pharmacological approaches to evaluate the interaction between the cannabinoid and cholinergic systems in cognitive processes;Bura;Br J Pharmacol,2007

4. Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice;Chabrol;Brain,2010

5. Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune diseases of the central nervous system;Dalmau;Physiol Rev,2017

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