Individualized cancer vaccines versus surveillance after adjuvant chemotherapy for surgically resected high-risk stage 2 and stage 3 colorectal cancer: protocol for a randomized trial

Author:

Jones Robert P12ORCID,Lee Lennard Y W3,Corrie Pippa G4,Danson Sarah5,Vimalachandran Dale16ORCID

Affiliation:

1. Department of Molecular & Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Liverpool , UK

2. Department of Hepatobiliary Surgery, Liverpool University Teaching Hospitals NHS Foundation Trust , Liverpool , UK

3. Department of Oncology, University of Oxford , Oxford , UK

4. Department of Oncology, Cambridge University Hospitals NHS Foundation Trust , Cambridge , UK

5. Department of Oncology, University of Sheffield, Western Bank , Sheffield , UK

6. Department of Colorectal Surgery, Countess of Chester NHS Foundation Trust , Chester , UK

Publisher

Oxford University Press (OUP)

Subject

Surgery

Reference6 articles.

1. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185;Sung,2021

2. Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer;Kotani;Nat Med,2023

3. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer;Sahin;Nature,2017

4. Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer;Rojas;Nature,2023

5. Microsatellite instability in colorectal cancer: overview of its clinical significance and novel perspectives;Battaglin;Clin Adv Hematol Oncol,2018

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1. Emerging advances in delivery systems for mRNA cancer vaccines;Journal of Controlled Release;2024-06

2. Lesional liver biopsies: better treatments, better studies, better science;British Journal of Surgery;2024-05

3. Current and future genomic applications for surgeons;The Annals of The Royal College of Surgeons of England;2024-04

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