Clinical and Pathologic Factors Associated With Colonic Spirochete (Brachyspira pilosicoli and Brachyspira aalborgi) Infection: A Comprehensive Systematic Review and Pooled Analysis

Author:

Eslick Guy D1ORCID,Fan Kening1,Nair Prema M1,Burns Grace L1,Hoedt Emily C1,Keely Simon1,Talley Nicholas J1

Affiliation:

1. NHMRC Centre for Research Excellence in Digestive Health, The University of Newcastle, Hunter Medical Research Institute (HMRI) , Callaghan , Australia

Abstract

Abstract Objectives This study aims to determine what pathologic and clinical factors differentiate Brachyspira species that may be useful to clinicians and pathologists. Methods We identified 21 studies of Brachyspira infection with individual patient information (n = 113) and conducted a pooled analysis comparing each species. Results There were differences in the pathologic and clinical profiles of each Brachyspira species. Patients infected with Brachyspira pilosicoli infection were more likely to have diarrhea, fever, HIV, and immunocompromised conditions. Those patients infected with Brachyspira aalborgi were more likely to have lamina propria inflammation. Conclusions Our novel data provide potential insights into the pathogenic mechanism(s) and the specific risk factor profile of Brachyspira species. This may be clinically useful when assessing and managing patients.

Funder

National Health and Medical Research Council

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Reference47 articles.

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