1. Vascular Medicine and Biology Theme, Biosciences Institute, Newcastle University, International Centre for Life , Times Square, Newcastle upon Tyne, NE1 4EP , UK
2. Peter-Osypka Heart Centre Munich, Internistisches Klinikum München Süd , Am Isarkanal 36, 81379 München, Munich , Germany
3. Technical University of Munich , Arcisstraße 21, 80333 München, Munich , Germany
4. Department of Cardiology, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Freeman Rd, High Heaton , Newcastle upon Tyne, NE7 7DN , UK